{"id":10293,"date":"2026-01-31T01:41:26","date_gmt":"2026-01-31T01:41:26","guid":{"rendered":"https:\/\/pharmamachinecn.com\/?p=10293"},"modified":"2026-03-12T02:40:36","modified_gmt":"2026-03-12T02:40:36","slug":"understanding-hot-melt-extrusion-formulation","status":"publish","type":"post","link":"https:\/\/pharmamachinecn.com\/ja\/understanding-hot-melt-extrusion-formulation\/","title":{"rendered":"\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\u306e\u914d\u5408\u3092\u7406\u89e3\u3059\u308b"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"10293\" class=\"elementor elementor-10293\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-656075b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"656075b4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-78348194\" data-id=\"78348194\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b902b66 product-data-tab elementor-widget elementor-widget-text-editor\" data-id=\"2b902b66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u7814\u7a76\u306b\u3088\u308b\u3068 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4766118\/\" target=\"_blank\" rel=\"noopener\"><u>50%\u306e\u5168\u6709\u52b9\u533b\u85ac\u54c1\u6210\u5206<\/u><\/a>\u00a0\uff08API\uff09\u306f\u6c34\u6eb6\u6027\u304c\u4f4e\u3044\u305f\u3081\u3001\u88fd\u5264\u306e\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u304c\u5236\u9650\u3055\u308c\u3001\u6cbb\u7642\u52b9\u679c\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u3053\u306e\u8ab2\u984c\u306b\u3088\u308a\u3001\u85ac\u7269\u5438\u53ce\u3092\u5411\u4e0a\u3055\u305b\u308b\u9769\u65b0\u7684\u306a\u6280\u8853\u306e\u5fc5\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002.<\/p><p>\u3053\u306e\u70b9\u306b\u304a\u3044\u3066\u3001\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u30a8\u30af\u30b9\u30c8\u30eb\u30fc\u30b8\u30e7\u30f3\u88fd\u5264\u306f\u52b9\u679c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u52b9\u7387\u7684\u306a\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5b89\u5b9a\u3057\u305f\u54c1\u8cea\u306e\u533b\u85ac\u54c1\u3092\u751f\u7523\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3067\u306f\u3001\u4e3b\u8981\u30d7\u30ed\u30bb\u30b9\u306b\u3064\u3044\u3066\u5305\u62ec\u7684\u306b\u3054\u8aac\u660e\u3057\u307e\u3057\u3087\u3046\u3002<\/p><h2><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u3057\u51fa\u3057\u914d\u5408\u3068\u306f\u4f55\u3067\u3059\u304b?<\/strong><\/h2><p>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\uff08HME\uff09\u306f\u3001\u9023\u7d9a\u7684\u306a<a href=\"https:\/\/pharmamachinecn.com\/ja\/how-are-medicine-tablets-made\/\"><u>\u00a0\u533b\u85ac\u54c1\u88fd\u9020\u30d7\u30ed\u30bb\u30b9<\/u><\/a>. \u3053\u306e\u6280\u8853\u3067\u306f\u3001\u85ac\u5264\u3068\u30dd\u30ea\u30de\u30fc\u3092\u5236\u5fa1\u3055\u308c\u305f\u6761\u4ef6\u4e0b\u3067\u6df7\u5408\u3057\u307e\u3059\u3002\u958b\u767a\u8005\u306f\u6b63\u78ba\u306a\u6e29\u5ea6\u3068\u5727\u529b\u3092\u8a2d\u5b9a\u3057\u3001\u5747\u4e00\u306a\u5206\u6563\u6db2\u3092\u5f62\u6210\u3057\u307e\u3059\u3002.<\/p><figure id=\"attachment_10385\" aria-describedby=\"caption-attachment-10385\" style=\"width: 1000px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-10385\" src=\"https:\/\/pharmamachinecn.com\/wp-content\/uploads\/2026\/01\/Hot-Melt-Extrusion-Formulation.jpg\" alt=\"\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\u7528\u914d\u5408\" width=\"1000\" height=\"742\" srcset=\"https:\/\/pharmamachinecn.com\/wp-content\/uploads\/2026\/01\/Hot-Melt-Extrusion-Formulation.jpg 1000w, https:\/\/pharmamachinecn.com\/wp-content\/uploads\/2026\/01\/Hot-Melt-Extrusion-Formulation-300x223.jpg 300w, https:\/\/pharmamachinecn.com\/wp-content\/uploads\/2026\/01\/Hot-Melt-Extrusion-Formulation-768x570.jpg 768w, https:\/\/pharmamachinecn.com\/wp-content\/uploads\/2026\/01\/Hot-Melt-Extrusion-Formulation-16x12.jpg 16w, https:\/\/pharmamachinecn.com\/wp-content\/uploads\/2026\/01\/Hot-Melt-Extrusion-Formulation-600x445.jpg 600w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><figcaption id=\"caption-attachment-10385\" class=\"wp-caption-text\"><em><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u3057\u51fa\u3057\u914d\u5408\u30d5\u30ed\u30fc\u30c1\u30e3\u30fc\u30c8\u3002.<\/strong><\/em><\/figcaption><\/figure><p>\u3053\u306e\u6280\u8853\u306f\u5f93\u6765\u306e\u65b9\u6cd5\u3068\u306f\u7570\u306a\u308a\u3001\u6eb6\u5a92\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u533b\u85ac\u54c1\u88fd\u5264\u306b\u3068\u3063\u3066\u3088\u308a\u6301\u7d9a\u53ef\u80fd\u306a\u9078\u629e\u80a2\u3068\u306a\u308a\u307e\u3059\u3002.<a href=\"https:\/\/www.researchgate.net\/publication\/378222474_Hot-Melt_Extrusion_from_Theory_to_Application_in_Pharmaceutical_Formulation-Where_Are_We_Now\" target=\"_blank\" rel=\"noopener\"><u>\u00a0ResearchGate\u306fHME\u304c\u975e\u5e38\u306b\u512a\u5148\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b<\/u><\/a>\u00a0\u6eb6\u5264\u3092\u4f7f\u308f\u305a\u74b0\u5883\u306b\u512a\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a1\u7528\u3057\u3066\u3044\u307e\u3059\u3002.<\/p><h2><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\u306e\u30d7\u30ed\u30bb\u30b9<\/strong><\/h2><p>\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u30dd\u30ea\u30de\u30fc\u3092\u6eb6\u878d\u3057\u3001\u6a5f\u68b0\u7684\u306a\u529b\u3092\u7528\u3044\u3066API\u3092\u7d44\u307f\u8fbc\u307f\u307e\u3059\u3002\u3053\u306e\u6eb6\u878d\u6df7\u5408\u7269\u3092\u62bc\u51fa\u6a5f\u306e\u30c0\u30a4\u306b\u62bc\u3057\u8fbc\u307f\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u5747\u8cea\u306a\u88fd\u54c1\u304c\u5f62\u6210\u3055\u308c\u307e\u3059\u3002\u51b7\u5374\u5f8c\u3001\u62bc\u51fa\u7269\u306f\u6240\u671b\u306e\u5264\u5f62\u306b\u6210\u5f62\u3055\u308c\u307e\u3059\u3002\u9320\u5264\u3001\u30da\u30ec\u30c3\u30c8\u3001\u30d5\u30a3\u30eb\u30e0\u306a\u3069\u304c\u305d\u306e\u4f8b\u3067\u3059\u3002\u4ee5\u4e0b\u306b\u624b\u9806\u3092\u9806\u3092\u8ffd\u3063\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p><h3><strong>1. \u7d66\u990c<\/strong><\/h3><p>\u85ac\u5264\u3068\u8ce6\u5f62\u5264\u3092\u4e88\u3081\u6df7\u5408\u3057\u305f\u6df7\u5408\u7269\u3092\u3001\u307e\u305a\u30db\u30c3\u30d1\u30fc\u304b\u3089\u62bc\u51fa\u6a5f\u306b\u6295\u5165\u3057\u307e\u3059\u3002\u3053\u306e\u5de5\u7a0b\u306b\u3088\u308a\u3001\u3059\u3079\u3066\u306e\u6210\u5206\u304c\u5236\u5fa1\u3055\u308c\u305f\u901f\u5ea6\u3067\u30b7\u30b9\u30c6\u30e0\u5185\u306b\u6295\u5165\u3055\u308c\u307e\u3059\u3002\u9069\u5207\u306a\u4f9b\u7d66\u306f\u3001\u5747\u4e00\u306a\u7d44\u6210\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002.<\/p><h3><strong>2. \u52a0\u71b1\u3068\u6df7\u5408<\/strong><\/h3><p>\u62bc\u51fa\u6a5f\u5185\u3067\u306f\u3001\u6df7\u5408\u7269\u306f\u5236\u5fa1\u3055\u308c\u305f\u52a0\u71b1\u3068\u305b\u3093\u65ad\u529b\u306b\u3055\u3089\u3055\u308c\u307e\u3059\u3002\u30dd\u30ea\u30de\u30fc\u304c\u6eb6\u878d\u3057\u3001\u85ac\u5264\u3092\u5747\u4e00\u306b\u5206\u6563\u3055\u305b\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u5747\u4e00\u306a\u6df7\u5408\u7269\u304c\u5f97\u3089\u308c\u307e\u3059\u3002.<\/p><h3><strong>3. \u62bc\u3057\u51fa\u3057<\/strong><\/h3><p>\u6eb6\u878d\u3057\u305f\u6750\u6599\u306f\u30c0\u30a4\u306b\u62bc\u3057\u51fa\u3055\u308c\u3001\u6240\u671b\u306e\u5f62\u72b6\u3068\u5bf8\u6cd5\u306e\u62bc\u51fa\u6210\u5f62\u54c1\u304c\u4f5c\u3089\u308c\u307e\u3059\u3002.<\/p><h3><strong>4. \u51b7\u5374\u3068\u7c89\u7815<\/strong><\/h3><p>\u62bc\u3057\u51fa\u3057\u7269\u306f\u51b7\u5374\u3055\u308c\u3001\u9069\u5207\u306a\u30b5\u30a4\u30ba\u306b\u7c89\u7815\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u5de5\u7a0b\u306b\u3088\u308a\u3001\u3055\u3089\u306b\u52a0\u5de5\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<a href=\"https:\/\/pharmamachinecn.com\/ja\/what-is-solid-dosage-formulation\/\"><u>\u00a0\u56fa\u5f62\u5264\u5f62<\/u><\/a>.<\/p><h2><strong>HME\u30d7\u30ed\u30bb\u30b9\u3067\u4f7f\u7528\u3055\u308c\u308b\u6a5f\u5668<\/strong><\/h2><p>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\u306e\u6210\u529f\u306f\u3001\u4e3b\u306b\u5c02\u7528\u6a5f\u5668\u306e\u4f7f\u7528\u306b\u304b\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4e3b\u306a\u6a5f\u5668\u306b\u306f\u4ee5\u4e0b\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p><h3><strong>\u30d5\u30a3\u30fc\u30c0\u30fc<\/strong><\/h3><p>\u30d5\u30a3\u30fc\u30c0\u30fc\u306f\u3001\u62bc\u51fa\u6a5f\u306b\u6df7\u5408\u7269\u3092\u4f9b\u7d66\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u308b\u7cbe\u5bc6\u6a5f\u5668\u3067\u3059\u3002\u30d5\u30a3\u30fc\u30c0\u30fc\u306f\u3001\u6750\u6599\u306e\u4f9b\u7d66\u901f\u5ea6\u3092\u8abf\u7bc0\u3057\u3066\u3001\u5b89\u5b9a\u3057\u305f\u6750\u6599\u306e\u6d41\u308c\u3092\u7dad\u6301\u3057\u307e\u3059\u3002.<\/p><h3><strong>\u30c4\u30a4\u30f3\u30b9\u30af\u30ea\u30e5\u30fc\u62bc\u51fa\u6a5f\uff08TSE\uff09<\/strong><\/h3><p>HME\u30d7\u30ed\u30bb\u30b9\u306e\u4e2d\u6838\u3068\u306a\u308b\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8\u306f\u3001\u4e8c\u8ef8\u30b9\u30af\u30ea\u30e5\u30fc\u62bc\u51fa\u6a5f\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u52a0\u71b1\u3055\u308c\u305f\u30d0\u30ec\u30eb\u5185\u3067\u56de\u8ee2\u3059\u308b2\u3064\u306e\u565b\u307f\u5408\u3063\u305f\u30b9\u30af\u30ea\u30e5\u30fc\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002.<\/p><p>\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u7570\u306a\u308b\u6e29\u5ea6\u30be\u30fc\u30f3\u3092\u4ecb\u3057\u305f\u52b9\u7387\u7684\u306a\u6df7\u5408\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u30dd\u30ea\u30de\u30fc\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5185\u3067\u306e\u5747\u4e00\u306a\u85ac\u5264\u5206\u6563\u304c\u4fdd\u8a3c\u3055\u308c\u307e\u3059\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38355916\/\" target=\"_blank\" rel=\"noopener\"><u>\u00a0\u56fd\u7acb\u533b\u5b66\u56f3\u66f8\u9928<\/u><\/a>\u00a0TSE \u304c\u52b9\u7387\u7684\u306a\u6df7\u5408\u3068\u9020\u7c92\u3092\u5b9f\u73fe\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002.<\/p><h3><strong>\u6696\u623f\u30b7\u30b9\u30c6\u30e0<\/strong><\/h3><p>\u62bc\u51fa\u6a5f\u5185\u306e\u6e29\u5ea6\u3092\u5236\u5fa1\u3059\u308b\u306b\u306f\u3001\u52a0\u71b1\u30b7\u30b9\u30c6\u30e0\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u85ac\u5264\u306e\u52a3\u5316\u3092\u62db\u304f\u3053\u3068\u306a\u304f\u30dd\u30ea\u30de\u30fc\u304c\u5747\u4e00\u306b\u6eb6\u878d\u3059\u308b\u3053\u3068\u304c\u4fdd\u8a3c\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u3053\u306e\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308a\u3001\u88fd\u5264\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u6700\u9069\u306a\u51e6\u7406\u6761\u4ef6\u304c\u7dad\u6301\u3055\u308c\u307e\u3059\u3002.<\/p><h3><strong>\u91d1\u578b\u7d44\u7acb<\/strong><\/h3><p>\u91d1\u578b\u306e\u4e2d\u5fc3\u7684\u306a\u6a5f\u80fd\u306f\u3001\u88fd\u54c1\u306e\u5f62\u72b6\u3092\u30ad\u30e5\u30ec\u30fc\u30c8\u3059\u308b\u3053\u3068\u3067\u3059\u3002<a href=\"https:\/\/pharmamachinecn.com\/ja\/standard-tablet-punch-and-die-size-chart-explained\/\"><u>\u00a0\u91d1\u578b\u8a2d\u8a08\u306e\u8abf\u6574<\/u><\/a>, \u88fd\u9020\u696d\u8005\u306f\u3001\u5e0c\u671b\u3059\u308b\u5264\u5f62\u3092\u88fd\u9020\u3067\u304d\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u5186\u5f62\u306e\u9320\u5264\u3092\u88fd\u9020\u3059\u308b\u306b\u306f\u3001\u4e38\u578b\u30c0\u30a4\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002.<\/p><h3><strong>\u51b7\u5374\u30b3\u30f3\u30d9\u30a2<\/strong><\/h3><p>\u30c0\u30a4\u7d44\u7acb\u5f8c\u3001\u62bc\u51fa\u7269\u306f\u901a\u5e38\u9ad8\u6e29\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u88fd\u54c1\u3092\u56fa\u3081\u308b\u306b\u306f\u3001\u51b7\u5374\u30b3\u30f3\u30d9\u30a2\u304c\u52b9\u679c\u7684\u3067\u3059\u3002\u9069\u5207\u306a\u51b7\u5374\u306f\u88fd\u54c1\u306e\u69cb\u9020\u3092\u7dad\u6301\u3057\u3001\u5909\u5f62\u3092\u9632\u304e\u307e\u3059\u3002.<\/p><h3><strong>\u30da\u30ec\u30bf\u30a4\u30b6\u30fc\u307e\u305f\u306f\u30ab\u30c3\u30bf\u30fc<\/strong><\/h3><p>\u30da\u30ec\u30bf\u30a4\u30b6\u30fc\u306f\u3001\u51b7\u5374\u3055\u308c\u305f\u62bc\u51fa\u7269\u3092\u5747\u4e00\u306a\u30da\u30ec\u30c3\u30c8\u307e\u305f\u306f\u9846\u7c92\u306b\u5207\u65ad\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u5f8c\u306b\u9320\u5264\u307e\u305f\u306f\u30ab\u30d7\u30bb\u30eb\u306b\u52a0\u5de5\u3055\u308c\u307e\u3059\u3002.<\/p><h3><strong>\u4e0b\u6d41\u51e6\u7406\u88c5\u7f6e<\/strong><\/h3><p>\u4e0b\u6d41\u5de5\u7a0b\u306e\u8a2d\u5099\u306b\u306f\u3001\u30d6\u30ec\u30f3\u30c0\u30fc\u3001\u6253\u9320\u6a5f\u3001\u30b3\u30fc\u30c6\u30a3\u30f3\u30b0\u6a5f\u306a\u3069\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306f\u6700\u7d42\u7684\u306a\u533b\u85ac\u54c1\u306e\u4ed5\u4e0a\u304c\u308a\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002.<\/p><div style=\"overflow-x: auto; width: 100%;\"><table style=\"min-width: 700px; border-collapse: collapse;\"><tbody><tr><td width=\"208\"><strong>\u88c5\u7f6e<\/strong><\/td><td width=\"208\"><strong>\u8aac\u660e<\/strong><\/td><td width=\"208\"><strong>\u95a2\u6570<\/strong><\/td><\/tr><tr><td width=\"208\">\u30d5\u30a3\u30fc\u30c0\u30fc<\/td><td width=\"208\">\u6df7\u5408\u7269\u3092\u62bc\u51fa\u6a5f\u306b\u9001\u308a\u8fbc\u3080<\/td><td width=\"208\">\u5747\u4e00\u306a\u7d44\u6210\u306e\u305f\u3081\u306b\u5b89\u5b9a\u3057\u305f\u6d41\u308c\u3092\u8abf\u7bc0\u3059\u308b<\/td><\/tr><tr><td width=\"208\">\u30c4\u30a4\u30f3\u30b9\u30af\u30ea\u30e5\u30fc\u62bc\u51fa\u6a5f<\/td><td width=\"208\">2\u3064\u306e\u56de\u8ee2\u30cd\u30b8\u3092\u5099\u3048\u305f\u672c\u4f53<\/td><td width=\"208\">\u6750\u6599\u3092\u5747\u4e00\u306b\u6df7\u305c\u3001\u6eb6\u304b\u3057\u3001\u5206\u6563\u3055\u305b\u307e\u3059\u3002.<\/td><\/tr><tr><td width=\"208\">\u6696\u623f\u30b7\u30b9\u30c6\u30e0<\/td><td width=\"208\">\u62bc\u51fa\u6a5f\u30d0\u30ec\u30eb\u306b\u6cbf\u3063\u3066\u71b1\u3092\u8abf\u7bc0\u3059\u308b<\/td><td width=\"208\">\u85ac\u5264\u3092\u52a3\u5316\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u30dd\u30ea\u30de\u30fc\u3092\u6eb6\u304b\u3059\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002.<\/td><\/tr><tr><td width=\"208\">\u91d1\u578b\u7d44\u7acb<\/td><td width=\"208\">\u62bc\u3057\u51fa\u3057\u6a5f\u306e\u7aef\u306b\u3042\u308b\u6210\u5f62\u30c4\u30fc\u30eb<\/td><td width=\"208\">\u6eb6\u878d\u6df7\u5408\u7269\u3092\u6240\u671b\u306e\u5f62\u72b6\u306b\u5909\u63db\u3059\u308b<\/td><\/tr><tr><td width=\"208\">\u51b7\u5374\u30b3\u30f3\u30d9\u30a2<\/td><td width=\"208\">\u62bc\u3057\u51fa\u3057\u5f8c\u306b\u4f7f\u7528\u3055\u308c\u308b\u30b7\u30b9\u30c6\u30e0\u3002.<\/td><td width=\"208\">\u62bc\u3057\u51fa\u3057\u305f\u3082\u306e\u3092\u51b7\u5374\u3057\u3066\u56fa\u3081\u3001\u5f62\u72b6\u3092\u7dad\u6301\u3057\u307e\u3059\u3002.<\/td><\/tr><tr><td width=\"208\">\u30da\u30ec\u30bf\u30a4\u30b6\u30fc\/\u30ab\u30c3\u30bf\u30fc<\/td><td width=\"208\">\u51b7\u5374\u5f8c\u306b\u4f7f\u7528\u3055\u308c\u308b\u6a5f\u68b0\u5f0f\u30ab\u30c3\u30bf\u30fc\u3002.<\/td><td width=\"208\">\u62bc\u3057\u51fa\u3057\u305f\u3082\u306e\u3092\u5747\u4e00\u306a\u30da\u30ec\u30c3\u30c8\u307e\u305f\u306f\u9846\u7c92\u306b\u5207\u65ad\u3057\u307e\u3059\u3002.<\/td><\/tr><tr><td width=\"208\">\u4e0b\u6d41\u8a2d\u5099<\/td><td width=\"208\">\u30d6\u30ec\u30f3\u30c0\u30fc\u3001\u30bf\u30d6\u30ec\u30c3\u30c8\u30d7\u30ec\u30b9\u3001\u30b3\u30fc\u30bf\u30fc\u306a\u3069\u304c\u542b\u307e\u308c\u307e\u3059\u3002.<\/td><td width=\"208\">\u30da\u30ec\u30c3\u30c8\u3092\u6700\u7d42\u5264\u5f62\u306b\u5909\u63db\u3059\u308b<\/td><\/tr><\/tbody><\/table><\/div><h2><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\u306e\u7528\u9014<\/strong><\/h2><p>HME\u6280\u8853\u306f\u533b\u85ac\u54c1\u5206\u91ce\u3067\u5e45\u5e83\u3044\u7528\u9014\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u6982\u8981\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p><h3><strong>\u56fa\u4f53\u5206\u6563\u4f53:<\/strong><\/h3><p>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u30a8\u30af\u30b9\u30c8\u30eb\u30fc\u30b8\u30e7\u30f3\u88fd\u5264\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u7528\u9014\u306e\u4e00\u3064\u306f\u3001\u56fa\u4f53\u5206\u6563\u4f53\u306e\u958b\u767a\u3067\u3059\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u96e3\u6eb6\u6027\u85ac\u7269\u3092\u975e\u6676\u8cea\u72b6\u614b\u306b\u5909\u63db\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u6eb6\u89e3\u901f\u5ea6\u304c\u5411\u4e0a\u3057\u3001\u4f53\u5185\u3067\u306e\u85ac\u7269\u306e\u52b9\u679c\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002.<\/p><h3><strong>\u5236\u5fa1\u653e\u51fa\u304a\u3088\u3073\u6301\u7d9a\u653e\u51fa\u30b7\u30b9\u30c6\u30e0<\/strong><\/h3><p>\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u308a\u3001\u85ac\u5264\u306e\u653e\u51fa\u901f\u5ea6\u3092\u6b63\u78ba\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u983b\u7e41\u306a\u6295\u4e0e\u306e\u5fc5\u8981\u6027\u304c\u8efd\u6e1b\u3055\u308c\u3001\u6cbb\u7642\u52b9\u679c\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002.<\/p><h3><strong>\u5473\u899a\u30de\u30b9\u30ad\u30f3\u30b0<\/strong><\/h3><p>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6210\u5f62\u306f\u3001\u7279\u5b9a\u306e\u85ac\u5264\u306e\u4e0d\u5feb\u306a\u5473\u3092\u96a0\u3059\u306e\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\u3002<a href=\"https:\/\/pharmamachinecn.com\/ja\/api-in-pharmaceutical-industry-explained\/\"><u>\u00a0API\u306e\u57cb\u3081\u8fbc\u307f<\/u><\/a>\u00a0\u30dd\u30ea\u30de\u30fc\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5185\u3067\u306f\u82e6\u5473\u304c\u52b9\u679c\u7684\u306b\u30d6\u30ed\u30c3\u30af\u3055\u308c\u307e\u3059\u3002.<\/p><h3><strong>\u6eb6\u5264\u30d5\u30ea\u30fc\u51e6\u7406\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3<\/strong><\/h3><p>HME\u6280\u8853\u306f\u6eb6\u5a92\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3002\u4e0d\u5b89\u5b9a\u306a\u85ac\u5264\u3084\u6c34\u5206\u3084\u6eb6\u5a92\u306b\u654f\u611f\u306a\u85ac\u5264\u306b\u975e\u5e38\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7279\u5fb4\u306b\u3088\u308a\u3001\u5f93\u6765\u306e\u6280\u8853\u3068\u6bd4\u8f03\u3057\u3066\u3088\u308a\u5b89\u5168\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306a\u308a\u307e\u3059\u3002.<\/p><h2><strong>\u3088\u304f\u3042\u308b\u8cea\u554f<\/strong><\/h2><h3><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u3057\u51fa\u3057\u88fd\u5264\u306b\u9069\u3057\u305f\u85ac\u5264\u306e\u7a2e\u985e\u306f\u4f55\u3067\u3059\u304b?<\/strong><\/h3><p>\u3053\u306e\u6280\u8853\u306f\u96e3\u6eb6\u6027\u85ac\u7269\u306b\u6700\u9069\u3067\u3059\u3002\u307e\u305f\u3001\u71b1\u306b\u654f\u611f\u306a\u88fd\u5264\u3082HME\u6cd5\u3067\u51e6\u7406\u3067\u304d\u307e\u3059\u3002.<\/p><h3><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u3057\u51fa\u3057\u306f\u6eb6\u5264\u3092\u4f7f\u7528\u3057\u306a\u3044\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u304b?<\/strong><\/h3><p>\u306f\u3044\u3002HME\u306f\u6eb6\u5264\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u6c34\u5206\u306b\u654f\u611f\u306a\u85ac\u5264\u306b\u3082\u9069\u3057\u3066\u3044\u307e\u3059\u3002.<\/p><h3><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u6280\u8853\u306e\u5c06\u6765\u3068\u306f\uff1f<\/strong><\/h3><p>\u5c06\u6765\u306f\u975e\u5e38\u306b\u6709\u671b\u3067\u3059\u3002\u9023\u7d9a\u88fd\u9020\u3068\u306e\u7d71\u5408\u306b\u3088\u308a\u3001\u9ad8\u54c1\u8cea\u306a\u533b\u85ac\u54c1\u3092\u751f\u7523\u3059\u308b\u53ef\u80fd\u6027\u304c\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u3002.<\/p><h2><strong>\u7d50\u8ad6<\/strong><\/h2><p>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u30a8\u30af\u30b9\u30c8\u30eb\u30fc\u30b8\u30e7\u30f3\u88fd\u5264\u306f\u3001\u533b\u85ac\u54c1\u88fd\u9020\u306b\u304a\u3051\u308b\u9769\u65b0\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002\u3088\u308a\u52b9\u679c\u7684\u306a\u85ac\u7269\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u88fd\u54c1\u306e\u54c1\u8cea\u306f\u4f7f\u7528\u3059\u308b\u6a5f\u5668\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u5264\u5f62\u3092\u88fd\u9020\u3059\u308b\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u70b9\u3092\u691c\u8a0e\u3057\u3066\u304f\u3060\u3055\u3044\u3002 <a href=\"https:\/\/pharmamachinecn.com\/ja\/pharmaceutical-machinery\/\"><u>\u30d5\u30a1\u30a4\u30f3\u30c6\u30c3\u30af\u88fd\u85ac\u6a5f\u68b0\u3002.<\/u><\/a>\u00a0\u304a\u5ba2\u69d8\u306e\u30cb\u30fc\u30ba\u306b\u304a\u5fdc\u3048\u3059\u308b\u5e45\u5e83\u3044\u533b\u7642\u6a5f\u5668\u3092\u53d6\u308a\u63c3\u3048\u3066\u304a\u308a\u307e\u3059\u3002\u6700\u9ad8\u7d1a\u306e\u88fd\u54c1\u3092\u6d3b\u7528\u3057\u3066\u3001\u533b\u85ac\u54c1\u88fd\u9020\u306e\u52b9\u7387\u5316\u3092\u5b9f\u73fe\u3057\u307e\u3057\u3087\u3046\uff01<\/p><h2><strong>\u53c2\u8003\u6587\u732e:<\/strong><\/h2><p><a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/hot-melt-extrusion.html\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\"><em><strong>\u88fd\u85ac\u7523\u696d\u306b\u304a\u3051\u308b\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa<\/strong><\/em><\/span><\/a><\/p><p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378517320304944\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\"><em><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u30a8\u30af\u30b9\u30c8\u30eb\u30fc\u30b8\u30e7\u30f3\u306b\u3088\u308b\u30b7\u30af\u30ed\u30c7\u30ad\u30b9\u30c8\u30ea\u30f3\u7cfb\u30dd\u30ea\uff08\u64ec\u4f3c\uff09\u30ed\u30bf\u30ad\u30b5\u30f3\u306e\u7d4c\u76ae\u88fd\u5264\u7528\u7279\u6027\u306e\u6539\u5584<\/strong><\/em><\/span><\/a>.<\/p><p><a href=\"https:\/\/ascendiacdmo.com\/hot-melt-extrusion-formulation-manufacturing\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\"><em><strong>\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u30fb\u30a8\u30af\u30b9\u30c8\u30eb\u30fc\u30b8\u30e7\u30f3\u306e\u51e6\u65b9\u3068\u88fd\u9020<\/strong><\/em><\/span><\/a>.<\/p><p><a href=\"https:\/\/www.pharmaexcipients.com\/news\/hme-formulation-pva\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\"><em><strong>\u30dd\u30ea\u30d3\u30cb\u30eb\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u7528\u3044\u305f\u30db\u30c3\u30c8\u30e1\u30eb\u30c8\u62bc\u51fa\u88fd\u5264\u306b\u3088\u308b\u539f\u85ac\u6eb6\u89e3\u6027\u306e\u6539\u5584<\/strong><\/em><\/span><\/a>.<\/p><h2><b>\u8457\u4f5c\u6a29\u306b\u3064\u3044\u3066\u00a0<\/b><\/h2><p>\u30d5\u30a1\u30a4\u30f3\u30c6\u30c3\u30af\u30fb\u30b0\u30eb\u30fc\u30d7\u306e\u66f8\u9762\u306b\u3088\u308b\u4e8b\u524d\u306e\u660e\u793a\u7684\u306a\u627f\u8a8d\u304c\u306a\u3044\u9650\u308a\u3001\u672c\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u4e0a\u306e\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u8907\u88fd\u3001\u5909\u66f4\u3001\u516c\u958b\u3001\u8868\u793a\u3001\u9001\u4fe1\u3001\u305d\u306e\u4ed6\u306e\u65b9\u6cd5\u3067\u5229\u7528\u3057\u305f\u308a\u3001\u305d\u306e\u3088\u3046\u306a\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u4f55\u3089\u304b\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u69cb\u7bc9\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u4f7f\u7528\u8a31\u53ef\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u3061\u3089\u307e\u3067\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\uff1a <a href=\"mailto:info@pharmamachinecn.com\"><span style=\"text-decoration: underline;\">info@pharmamachinecn.com<\/span><\/a><\/p><h2><b>\u514d\u8cac\u4e8b\u9805:<\/b><\/h2><p>\u672c\u8a18\u4e8b\u306b\u542b\u307e\u308c\u308b\u60c5\u5831\u306f\u3001\u4e00\u822c\u7684\u306a\u60c5\u5831\u63d0\u4f9b\u306e\u307f\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u5f53\u793e\u306f\u3001\u3044\u304b\u306a\u308b\u60c5\u5831\u306b\u3064\u3044\u3066\u3082\u3001\u305d\u306e\u6b63\u78ba\u6027\u3001\u59a5\u5f53\u6027\u3001\u9069\u6642\u6027\u3001\u5b8c\u5168\u6027\u3092\u4fdd\u8a3c\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u307e\u305f\u3001\u672c\u8a18\u4e8b\u306e\u5185\u5bb9\u306e\u8aa4\u8b2c\u307e\u305f\u306f\u8131\u6f0f\u306b\u3064\u3044\u3066\u4e00\u5207\u306e\u8cac\u4efb\u3092\u8ca0\u3044\u307e\u305b\u3093\u3002.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Study shows that 50% of all active pharmaceutical ingredients\u00a0(APIs) exhibit poor water solubility. It leads to dosage forms with limited [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10385,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[67],"tags":[],"class_list":["post-10293","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pills"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/posts\/10293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/comments?post=10293"}],"version-history":[{"count":20,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/posts\/10293\/revisions"}],"predecessor-version":[{"id":13281,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/posts\/10293\/revisions\/13281"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/media\/10385"}],"wp:attachment":[{"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/media?parent=10293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/categories?post=10293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmamachinecn.com\/ja\/wp-json\/wp\/v2\/tags?post=10293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}