{"id":18354,"date":"2026-09-19T01:08:54","date_gmt":"2026-09-19T01:08:54","guid":{"rendered":"https:\/\/pharmamachinecn.com\/?p=18354"},"modified":"2026-06-08T08:30:23","modified_gmt":"2026-06-08T08:30:23","slug":"moisture-activated-dry-granulation","status":"publish","type":"post","link":"https:\/\/pharmamachinecn.com\/tr\/moisture-activated-dry-granulation\/","title":{"rendered":"Nemle Etkinle\u015fen Kuru Gran\u00fclasyon"},"content":{"rendered":"
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Islak gran\u00fclasyon, \u00e7o\u011fumuzun hat\u0131rlayabildi\u011fi kadar\u0131yla tablet \u00fcretiminde her zaman en \u00e7ok tercih edilen y\u00f6ntem olmu\u015ftur. Tozunuzu s\u0131v\u0131 bir ba\u011flay\u0131c\u0131yla kar\u0131\u015ft\u0131r\u0131r, \u0131slak bir topak haline getirmek i\u00e7in yo\u011furur, f\u0131r\u0131nda kurutur ve ard\u0131ndan istenen boyuta gelene kadar \u00f6\u011f\u00fct\u00fcrs\u00fcn\u00fcz. Bu y\u00f6ntem i\u015fe yarar, ancak zaman al\u0131r, enerji t\u00fcketir ve sonuca her seferinde ayn\u0131 \u015fekilde ula\u015fmak zordur.<\/p>

\"MADG
MADG S\u00fcrecinin Proses Ak\u0131\u015f \u015eemas\u0131.<\/strong><\/em><\/figcaption><\/figure>

Kuru gran\u00fclasyon, s\u0131v\u0131 a\u015famas\u0131n\u0131 ortadan kald\u0131r\u0131r ancak kendi sorunlar\u0131n\u0131 da beraberinde getirir. Silindir s\u0131k\u0131\u015ft\u0131rma i\u015flemi tozu a\u015f\u0131r\u0131 derecede ezerek, genellikle iyi tabletler haline getirilemeyen ince par\u00e7ac\u0131klar ve topaklardan olu\u015fan bir kar\u0131\u015f\u0131m ortaya \u00e7\u0131kar\u0131r.<\/p>

Bu iki yakla\u015f\u0131m aras\u0131nda, \u201cnemle aktive edilen kuru gran\u00fclasyon\u201d (MADG) ad\u0131 verilen bir s\u00fcre\u00e7 yer almaktad\u0131r. Bu s\u00fcre\u00e7 ilk olarak 1987 y\u0131l\u0131nda Ullah ve meslekta\u015flar\u0131 taraf\u0131ndan tan\u0131mlanm\u0131\u015ft\u0131 ve 30 y\u0131l\u0131 a\u015fk\u0131n bir s\u00fcre ge\u00e7mesine ra\u011fmen, \u00e7o\u011fu ila\u00e7 \u015firketi h\u00e2l\u00e2 bu y\u00f6ntemi benimsememi\u015ftir. Bu durum tuhaft\u0131r, \u00e7\u00fcnk\u00fc teorik olarak \u0131slak gran\u00fclasyonu bu kadar sinir bozucu k\u0131lan sorunlar\u0131n \u00e7o\u011funu \u00e7\u00f6zmektedir.<\/p>

Peki, MADG tam olarak nedir?<\/b><\/strong><\/h2>

Bunu, hacim oran\u0131 olduk\u00e7a d\u00fc\u015f\u00fcr\u00fclm\u00fc\u015f bir \u0131slak gran\u00fclasyon i\u015flemi olarak d\u00fc\u015f\u00fcn\u00fcn. Tozunuzu a\u011f\u0131rl\u0131k\u00e7a 20 ila 50% suyla \u0131slatmak yerine (\u0131slak gran\u00fclasyonda standart olan miktar), MADG sadece 1 ila 4% su kullan\u0131r. Bu \u00e7ok az miktardaki su, ba\u011flay\u0131c\u0131y\u0131 yap\u0131\u015fkan hale getirip ince par\u00e7ac\u0131klar\u0131 birbirine yap\u0131\u015ft\u0131rarak k\u00fc\u00e7\u00fck gran\u00fcller olu\u015fturmaya yeter. Ancak bu miktar o kadar azd\u0131r ki, i\u015flemden sonra kurutucu \u00e7al\u0131\u015ft\u0131rman\u0131za gerek kalmaz.<\/p>

\u0130\u015fte as\u0131l mesele de bu. Kurutma a\u015famas\u0131 yok. \u00d6\u011f\u00fctme a\u015famas\u0131 da yok, \u00e7\u00fcnk\u00fc gran\u00fcller oldu\u011fu gibi kullan\u0131labilecek kadar k\u00fc\u00e7\u00fck \u00e7\u0131k\u0131yor. T\u00fcm i\u015flem, tek bir y\u00fcksek kesme kuvveti kar\u0131\u015ft\u0131r\u0131c\u0131s\u0131nda yakla\u015f\u0131k 10 ila 15 dakika i\u00e7inde tamamlan\u0131yor.<\/p>

\u0130ki A\u015fama<\/b><\/strong><\/h2>

MADG, iki ayr\u0131 a\u015famaya ayr\u0131l\u0131r. Her ikisi de ayn\u0131 ekipman i\u00e7inde, birbiri ard\u0131na ger\u00e7ekle\u015fir.<\/p>

Birinci a\u015fama, aglomerasyondur.<\/b><\/strong>\u00a0Aktif maddeyi, dolgu maddesi ve kuru bir ba\u011flay\u0131c\u0131 ile birlikte gran\u00fclat\u00f6re y\u00fcklersiniz. PVP K-12 ve HPC, yayg\u0131n olarak kullan\u0131lan ba\u011flay\u0131c\u0131 se\u00e7enekleridir. Her \u015feyi homojen bir k\u0131vam elde edene kadar kar\u0131\u015ft\u0131r\u0131n. Ard\u0131ndan, pervane h\u00e2l\u00e2 d\u00f6nerken tozun \u00fczerine az miktarda su p\u00fcsk\u00fcrt\u00fcn. Su damlac\u0131klar\u0131, ba\u011flay\u0131c\u0131y\u0131 yap\u0131\u015fkan hale getirecek kadar \u0131slat\u0131r. Par\u00e7ac\u0131klar birbirine \u00e7arparak birle\u015fir. Sonu\u00e7ta, 150 ila 500 mikron aral\u0131\u011f\u0131nda, k\u00fc\u00e7\u00fck, kabaca k\u00fcresel aglomeralar elde edersiniz. Form\u00fcl\u00fcn bu k\u0131sm\u0131 genellikle toplam parti a\u011f\u0131rl\u0131\u011f\u0131n\u0131n yakla\u015f\u0131k ila 'ini olu\u015fturur.<\/p>

\u0130kinci a\u015fama, nemin emilmesi ve da\u011f\u0131t\u0131lmas\u0131d\u0131r.<\/b><\/strong>\u00a0Birinci a\u015famadan \u00e7\u0131kan gran\u00fcllerin y\u00fczeyinde h\u00e2l\u00e2 bir miktar nem kal\u0131nt\u0131s\u0131 bulunur. Bunu gidermek i\u00e7in, kar\u0131\u015ft\u0131r\u0131c\u0131 \u00e7al\u0131\u015fmaya devam ederken nem emici yard\u0131mc\u0131 maddeler ekliyorsunuz. \u0130lk olarak mikrokristalin sel\u00fcloz eklenir ve suyun b\u00fcy\u00fck k\u0131sm\u0131n\u0131 emer. Ard\u0131ndan kolloidal silikon dioksit eklenir ve kalan nemi de emer. Her ikisi de kar\u0131\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, gran\u00fclasyon f\u0131r\u0131na girmeye gerek kalmadan kuru ve serbest ak\u0131\u015fl\u0131 hale gelir. Bundan sonra, par\u00e7alay\u0131c\u0131y\u0131 ekleyip kar\u0131\u015ft\u0131r\u0131n, kayganla\u015ft\u0131r\u0131c\u0131y\u0131 ekleyip tekrar kar\u0131\u015ft\u0131r\u0131n; art\u0131k preslemeye haz\u0131rs\u0131n\u0131z.<\/p>

Neden U\u011fra\u015fal\u0131m Ki? H\u0131zl\u0131 Bir Kar\u015f\u0131la\u015ft\u0131rma<\/b><\/strong><\/h2>
\u00a0<\/td>Islak Gran\u00fclasyon<\/b><\/strong><\/td>Kuru Gran\u00fclasyon<\/b><\/strong><\/td>MADG<\/b><\/strong><\/td><\/tr>
Kullan\u0131lan su<\/b><\/strong><\/td>20\u201350% toz a\u011f\u0131rl\u0131\u011f\u0131<\/td>Hi\u00e7biri<\/td>1\u201341 TP3T form\u00fcl a\u011f\u0131rl\u0131\u011f\u0131<\/td><\/tr>
Kurutma gereklidir<\/b><\/strong><\/td>Evet, genellikle saatler<\/td>Hay\u0131r<\/td>Hay\u0131r<\/td><\/tr>
Frezeleme gerekiyor<\/b><\/strong><\/td>Evet<\/td>Evet<\/td>Hay\u0131r<\/td><\/tr>
\u0130\u015flem s\u00fcresi<\/b><\/strong><\/td>\u00c7al\u0131\u015fma s\u00fcresi (gran\u00fclasyon + kurutma + \u00f6\u011f\u00fctme)<\/td>Il\u0131man<\/td>Toplam 10\u201315 dakika<\/td><\/tr>
U\u00e7 nokta duyarl\u0131l\u0131\u011f\u0131<\/b><\/strong><\/td>Y\u00fcksek<\/td>Il\u0131man<\/td>D\u00fc\u015f\u00fck<\/td><\/tr>
Te\u00e7hizat<\/b><\/strong><\/td>\u00d6\u011f\u00fct\u00fcc\u00fc + kurutucu + de\u011firmen<\/td>Silindirli s\u0131k\u0131\u015ft\u0131r\u0131c\u0131 + \u00f6\u011f\u00fct\u00fcc\u00fc<\/td>Yaln\u0131zca y\u00fcksek kesme kuvvetli gran\u00fclat\u00f6r<\/td><\/tr>
Is\u0131ya duyarl\u0131 aktif ila\u00e7 bile\u015fenleri i\u00e7in uygundur<\/b><\/strong><\/td>Riskli<\/td>Evet<\/td>Evet<\/td><\/tr><\/tbody><\/table><\/div>

Bir saniye \u015fu ortadaki s\u00fctuna bir bak\u0131n. Kuru gran\u00fclasyon, su ve \u0131s\u0131 kullan\u0131m\u0131n\u0131 ortadan kald\u0131r\u0131r; bu da g\u00fczel bir \u015fey. Ancak silindir s\u0131k\u0131\u015ft\u0131rma, tozu o kadar sert bir \u015fekilde eziyor ki, malzeme g\u00fc\u00e7l\u00fc tabletler haline getirilebilme \u00f6zelli\u011fini kaybediyor. Sonu\u00e7ta yumu\u015fak, ufalanan haplar elde ediyorsunuz. MADG, kaba kuvvet yerine \u0131slak ba\u011flay\u0131c\u0131n\u0131n ince bir tabakas\u0131yla par\u00e7ac\u0131klar\u0131 nazik\u00e7e birle\u015ftirerek bu sorunu ortadan kald\u0131r\u0131yor.<\/p>

\u00d6\u011feleri ekleme s\u0131ran\u0131z\u0131n ger\u00e7ekten \u00f6nemi var<\/b><\/strong><\/h2>

MADG konusunda insanlar\u0131 haz\u0131rl\u0131ks\u0131z yakalayan bir husus, bu i\u015flemin bile\u015fenlerin eklenme s\u0131ras\u0131na ne kadar duyarl\u0131 oldu\u011fudur. Islak gran\u00fclasyonda bu s\u0131ra konusunda olduk\u00e7a esnek bir yakla\u015f\u0131m s\u00f6z konusudur. MADG\u2019de ise durum b\u00f6yle de\u011fildir.<\/p>

Tipik bir MADG i\u015finin i\u015fleyi\u015fi \u015fu \u015fekildedir:<\/strong><\/h3>
  1. API\u2019yi, dolgu maddesini ve kuru ba\u011flay\u0131c\u0131y\u0131 gran\u00fclat\u00f6re y\u00fckleyin. Homojen bir kar\u0131\u015f\u0131m elde edilene kadar kar\u0131\u015ft\u0131r\u0131n.<\/strong><\/li>
  2. Pervane \u00e7al\u0131\u015f\u0131rken kar\u0131\u015f\u0131m\u0131n \u00fczerine 1\u20134% su p\u00fcsk\u00fcrt\u00fcn. Bu i\u015flem, nemli aglomeralar\u0131n olu\u015fmas\u0131n\u0131 sa\u011flar.<\/strong><\/li>
  3. Kar\u0131\u015ft\u0131rma devam ederken mikrokristalin sel\u00fcloz (MCC) ekleyin. MCC, y\u00fczeydeki nemin b\u00fcy\u00fck bir k\u0131sm\u0131n\u0131 emer.<\/strong><\/li>
  4. Kolloidal silikon dioksit ekleyin. Bu madde, MCC\u2019nin temizleyemedi\u011fi kalan nemi emer.<\/strong><\/li>
  5. Da\u011f\u0131t\u0131c\u0131y\u0131 ekleyin ve kar\u0131\u015ft\u0131r\u0131n.<\/strong><\/li>
  6. Ya\u011flay\u0131c\u0131y\u0131 (genellikle magnezyum stearat) ekleyin ve k\u0131sa bir s\u00fcre kar\u0131\u015ft\u0131r\u0131n.<\/strong><\/li>
  7. Tablet haline getirin.<\/strong><\/li><\/ol>

    3. ve 4. ad\u0131mlar\u0131 tersine \u00e7evirirseniz, elde etti\u011finiz gran\u00fclasyon h\u00e2l\u00e2 \u00e7ok \u0131slak olabilir. Silikon dioksiti tamamen kullanmazsan\u0131z ise, kar\u0131\u015f\u0131m presin besleme sistemine akacak kadar iyi ak\u0131\u015f g\u00f6stermeyebilir. Bunlar, s\u00fcrecin ba\u015far\u0131s\u0131n\u0131 ya da ba\u015far\u0131s\u0131zl\u0131\u011f\u0131n\u0131 belirleyen k\u00fc\u00e7\u00fck ayr\u0131nt\u0131lard\u0131r.<\/p>

    MADG\u2019nin Ger\u00e7ekten \u00d6ne \u00c7\u0131kt\u0131\u011f\u0131 Alanlar<\/b><\/strong><\/h2>

    Bu s\u00fcre\u00e7, \u00f6zellikle y\u00fcksek ila\u00e7 y\u00fck\u00fcne sahip form\u00fcllerde ger\u00e7ek de\u011ferini ortaya koyar. \u0130lac\u0131n tablet a\u011f\u0131rl\u0131\u011f\u0131n\u0131n %\u2019sini veya daha fazlas\u0131n\u0131 olu\u015fturdu\u011fu durumlarda, \u0131slak gran\u00fclasyon s\u00fcreci olduk\u00e7a zorlu hale gelir. Devasa bir ila\u00e7 y\u0131\u011f\u0131n\u0131na bir ton su d\u00f6k\u00fcyorsunuz, ard\u0131ndan hepsini e\u015fit bir \u015fekilde kurutmaya \u00e7al\u0131\u015f\u0131yorsunuz. Bu i\u015flem sonsuza kadar s\u00fcrer ve a\u015f\u0131r\u0131 \u0131slanma ya da yetersiz kuruma olas\u0131l\u0131\u011f\u0131 h\u0131zla artar.<\/p>

    MADG, su miktar\u0131n\u0131n olduk\u00e7a s\u0131n\u0131rl\u0131 olmas\u0131 nedeniyle y\u00fcksek ila\u00e7 y\u00fcklerini iyi bir \u015fekilde i\u015fleyebilmektedir. Yap\u0131lan ara\u015ft\u0131rmalar, bu y\u00f6ntemin y\u00fcksek y\u00fcklerde metformin HCl, asetaminofen ve demir askorbat ile etkili oldu\u011funu g\u00f6stermi\u015ftir. Bu \u00fc\u00e7 ila\u00e7 da, hacim ve ak\u0131\u015f sorunlar\u0131 nedeniyle geleneksel gran\u00fclasyon y\u00f6ntemlerinde i\u015flenmesi zor olan ila\u00e7lard\u0131r.<\/p>

    Suyu sevmeyen ila\u00e7lar da bir ba\u015fka \u00f6nemli nokta. Islak gran\u00fclasyonda, yeterince \u0131slanmayan bir ila\u00e7 s\u00fcre\u00e7 boyunca size zorluk \u00e7\u0131kar\u0131r. D\u00fczensiz gran\u00fcller, yetersiz i\u00e7erik da\u011f\u0131l\u0131m\u0131, zay\u0131f tabletler. MADG y\u00f6nteminde su, ilac\u0131 de\u011fil ba\u011flay\u0131c\u0131y\u0131 hedef al\u0131r. Ba\u011flay\u0131c\u0131 yap\u0131\u015fkan hale gelir ve as\u0131l i\u015fi \u00fcstlenir. \u0130la\u00e7 ise sadece bu s\u00fcrece e\u015flik eder.<\/p>

    Is\u0131ya duyarl\u0131 bile\u015fikler listeyi tamaml\u0131yor. Kurutma f\u0131r\u0131n\u0131 olmamas\u0131, oda s\u0131cakl\u0131\u011f\u0131n\u0131n \u00fczerinde termal stresin ya\u015fanmayaca\u011f\u0131 anlam\u0131na gelir. E\u011fer aktif ila\u00e7 maddeniz (API) 40 veya 50 \u00b0C\u2019de bozulmaya ba\u015fl\u0131yorsa, MADG bu riski en ba\u015f\u0131ndan itibaren \u00f6nlemenizi sa\u011flar.<\/p>

    Ayr\u0131ca yeterince \u00fczerinde durulmayan bir maliyet boyutu da var. \u00dc\u00e7 ekipman yerine tek bir ekipman kullan\u0131yorsunuz. \u00c7al\u0131\u015ft\u0131r\u0131lacak kurutucu yok, temizlenecek \u00f6\u011f\u00fct\u00fcc\u00fc yok, kaplar aras\u0131 aktar\u0131m a\u015famalar\u0131 yok. Birden fazla \u00fcr\u00fcn aras\u0131nda s\u0131k\u0131 zaman \u00e7izelgeleriyle u\u011fra\u015fan bir CDMO i\u00e7in bu t\u00fcr bir h\u0131z \u00f6nemlidir.<\/p>

    Neler Ters Gidebilir?<\/b><\/strong><\/h2>

    MADG, \u0131slak gran\u00fclasyondan daha basittir, ancak hatas\u0131z bir y\u00f6ntem de\u011fildir. Baz\u0131 hususlar, kullan\u0131c\u0131lar\u0131n d\u00fczenli olarak zorlanmas\u0131na neden olmaktad\u0131r.<\/p>

    En \u00f6nemli fakt\u00f6r, ne kadar su ekledi\u011finizdir. \u00c7ok az su ekledi\u011finizde ba\u011flay\u0131c\u0131 asla yap\u0131\u015fkan hale gelmez. Sonu\u00e7ta, ger\u00e7ek bir gran\u00fclasyon de\u011fil, do\u011frudan kar\u0131\u015ft\u0131r\u0131lm\u0131\u015f bir kar\u0131\u015f\u0131m gibi g\u00f6r\u00fcnen ve davranan gev\u015fek bir toz elde edersiniz. \u00c7ok fazla su ekledi\u011finizde ise, MCC ve silikan\u0131n ememeyece\u011fi \u0131slak topaklar olu\u015fur. Bu noktada bir kurutucuya ihtiya\u00e7 duyars\u0131n\u0131z ve i\u015flemin t\u00fcm faydas\u0131 bo\u015fa gider.<\/p>

    Su damlalar\u0131n\u0131n boyutu da sand\u0131\u011f\u0131n\u0131zdan daha \u00f6nemlidir. Kaba bir p\u00fcsk\u00fcrtme ba\u015fl\u0131\u011f\u0131ndan \u00e7\u0131kan b\u00fcy\u00fck damlalar, parti genelinde e\u015fit bir nem da\u011f\u0131l\u0131m\u0131 sa\u011flamak yerine tozun \u00fczerinde \u0131slak lekeler olu\u015fturur. \u0130yi bir p\u00fcsk\u00fcrtme ba\u015fl\u0131\u011f\u0131ndan \u00e7\u0131kan ince sis ise suyu e\u015fit bir \u015fekilde yayar ve b\u00f6ylece ba\u011flay\u0131c\u0131 her yerde ayn\u0131 h\u0131zda etkinle\u015fir. Uygun bir p\u00fcsk\u00fcrtme sistemi olmadan bu i\u015flemi denemezdim. Bir beherden su d\u00f6kmek, ba\u015f\u0131n\u0131za bela a\u00e7mak demektir.<\/p>

    Bir de ba\u011flay\u0131c\u0131 se\u00e7imi var. Yay\u0131nlanan verilere g\u00f6re PVP K-12 ve HPC en g\u00fcvenli se\u00e7eneklerdir. Maltodekstrin DE16 de ara\u015ft\u0131rmalarda yer almaktad\u0131r. Hangi ba\u011flay\u0131c\u0131y\u0131 kullan\u0131rsan\u0131z kullan\u0131n, sadece 1 ila 4% su ile kuru tozdan yap\u0131\u015fkan bir y\u00fczeye d\u00f6n\u00fc\u015fmesi gerekir. Her ba\u011flay\u0131c\u0131 bunu ba\u015faramaz. Baz\u0131lar\u0131 etkinle\u015fmek i\u00e7in \u00e7ok daha fazla s\u0131v\u0131ya ihtiya\u00e7 duyar, bu da onlar\u0131 MADG i\u00e7in uygun olmayan se\u00e7enekler haline getirir.<\/p>

    P\u00fcsk\u00fcrtme a\u015famas\u0131ndaki kar\u0131\u015ft\u0131rma h\u0131z\u0131 ve s\u00fcresi de dikkat \u00e7ekmeye de\u011fer. H\u0131z \u00e7ok y\u00fcksek olursa, \u0131slak ba\u011flay\u0131c\u0131 madde ila\u00e7 par\u00e7ac\u0131klar\u0131na tutunamadan etrafa yay\u0131l\u0131r. H\u0131z \u00e7ok d\u00fc\u015f\u00fck olursa ise su tek bir noktada birikir. Her gran\u00fclat\u00f6r bu durumu biraz farkl\u0131 \u015fekilde ele al\u0131r; bu nedenle geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131 s\u0131ras\u0131nda pervane h\u0131z\u0131n\u0131 ayarlamak i\u00e7in biraz zaman ay\u0131rman\u0131z gerekecektir.<\/p>

    Evlat edinme s\u00fcreci neden bu kadar yava\u015f ilerliyor?<\/b><\/strong><\/h2>

    MADG hakk\u0131nda bir yaz\u0131 yaz\u0131ld\u0131\u011f\u0131nda her seferinde g\u00fcndeme gelen soru budur. Bu y\u00f6ntem 1987 y\u0131l\u0131nda yay\u0131nlanm\u0131\u015ft\u0131r. Islak gran\u00fclasyona k\u0131yasla daha basit, daha h\u0131zl\u0131 ve daha ucuzdur. Standart ekipmanlarla uygulan\u0131r. Yine de ila\u00e7 \u00fcreticilerinin \u00e7o\u011fu h\u00e2l\u00e2 bu y\u00f6ntemi denememi\u015ftir.<\/p>

    Bunun bir k\u0131sm\u0131 da atalet kaynakl\u0131d\u0131r. Islak gran\u00fclasyon, ila\u00e7 \u00fcretim k\u00fclt\u00fcr\u00fcn\u00fcn derinlerine i\u015flemi\u015ftir. Yasal ba\u015fvurular, standart \u00e7al\u0131\u015fma prosed\u00fcrleri (SOP\u2019ler), e\u011fitim programlar\u0131, do\u011frulama protokolleri\u2026 Bunlar\u0131n hepsi \u0131slak gran\u00fclasyon temelinde \u015fekillenmi\u015ftir. Yeni bir y\u00f6nteme ge\u00e7mek, yeni s\u00fcre\u00e7 nesnel olarak daha kolay olsa bile, \u00e7ok say\u0131da belgenin yeniden yaz\u0131lmas\u0131n\u0131 ve personelin yeniden e\u011fitilmesini gerektirir.<\/p>

    Bunun bir nedeni de konunun yeterince bilinmemesidir. MADG, \u00e7o\u011fu ila\u00e7 teknolojisi dersinde i\u015flenmemektedir. Bir form\u00fclat\u00f6r bu y\u00f6ntemi hi\u00e7 g\u00f6rmemi\u015fse, yeni bir \u00fcr\u00fcn i\u00e7in bunu \u00f6nerme olas\u0131l\u0131\u011f\u0131 d\u00fc\u015f\u00fckt\u00fcr. Sekt\u00f6rden baz\u0131 sesler, bu konunun daha geni\u015f kitlelere ula\u015fmas\u0131 i\u00e7in \u00fcniversitelerde ve meslek kurulu\u015flar\u0131nda daha fazla uygulamal\u0131 e\u011fitim program\u0131 d\u00fczenlenmesi \u00e7a\u011fr\u0131s\u0131nda bulunmu\u015ftur.<\/p>

    Bunun bir k\u0131sm\u0131 muhtemelen sadece ihtiyatl\u0131 olmaktan kaynaklan\u0131yor. \u0130la\u00e7 sekt\u00f6r\u00fc muhafazakar bir sekt\u00f6rd\u00fcr. Bir s\u00fcre\u00e7 i\u015fe yarad\u0131\u011f\u0131nda, daha iyi bir se\u00e7enek olsa bile insanlar o s\u00fcreci s\u00fcrd\u00fcr\u00fcr. Bu zihniyet yava\u015f yava\u015f de\u011fi\u015fiyor, ancak MADG\u2019nin hen\u00fcz yayg\u0131n olarak benimsenmesi i\u00e7in yeterince h\u0131zl\u0131 bir de\u011fi\u015fim ger\u00e7ekle\u015fmemi\u015ftir.<\/p>

    MADG\u2019nin B\u00fcy\u00fcmesini Ne Sa\u011flayabilir?<\/b><\/strong><\/h2>

    Bu s\u00fcreci ilerletmeye yard\u0131mc\u0131 olacak birka\u00e7 unsur vard\u0131r. \u00c7ok i\u015flevli yard\u0131mc\u0131 maddeler bunlardan biridir. Nem emici, par\u00e7alay\u0131c\u0131 ve kuru ba\u011flay\u0131c\u0131 olarak ayn\u0131 anda i\u015flev g\u00f6ren tek bir bile\u015fen d\u00fc\u015f\u00fcn\u00fcn. Bu, ekleme ad\u0131mlar\u0131n\u0131n say\u0131s\u0131n\u0131 azaltacak ve zaten basit olan s\u00fcreci daha da basitle\u015ftirecektir. Grace gibi \u015firketler, nemi verimli bir \u015fekilde emen mezopor\u00f6z silika yard\u0131mc\u0131 maddeleri geli\u015ftirmi\u015f durumda; bu da do\u011fru y\u00f6nde at\u0131lm\u0131\u015f bir ad\u0131md\u0131r.<\/p>

    S\u00fcrekli \u00fcretim, MADG\u2019nin yayg\u0131nla\u015fabilece\u011fi bir ba\u015fka aland\u0131r. Bu s\u00fcre\u00e7 k\u0131sad\u0131r, \u00e7ok az s\u0131v\u0131 kullan\u0131r ve ayr\u0131 bir kurutucuya ihtiya\u00e7 duymaz. Bu da onu, h\u0131z ve basitli\u011fin en \u00f6nemli unsurlar oldu\u011fu s\u00fcrekli gran\u00fclasyon hatlar\u0131 i\u00e7in do\u011fal bir aday haline getirir.<\/p>

    MADG\u2019ye \u00f6zel olarak tasarlanm\u0131\u015f daha geli\u015fmi\u015f PAT (proses analitik teknolojisi) ara\u00e7lar\u0131 da faydal\u0131 olacakt\u0131r; her ne kadar bu s\u00fcre\u00e7 \u0131slak gran\u00fclasyona k\u0131yasla daha az de\u011fi\u015fken i\u00e7erse de. P\u00fcsk\u00fcrtme a\u015famas\u0131nda ger\u00e7ek zamanl\u0131 nem izlemesi, s\u00fcreci daha da sa\u011flam hale getirebilir ve d\u00fczenleyici kurumlara ba\u015fvurularda g\u00f6rmek istedikleri verileri sa\u011flayabilir.<\/p>

    Denemek \u0130sterseniz Birka\u00e7 Pratik \u0130pucu<\/b><\/strong><\/h2>

    \u0130yi bildi\u011finiz bir ila\u00e7la ba\u015flay\u0131n. Islak gran\u00fclasyonun zaten i\u015fe yarad\u0131\u011f\u0131, ancak \u00e7ok uzun s\u00fcrd\u00fc\u011f\u00fc ya da kurutma a\u015famas\u0131nda sorun \u00e7\u0131kard\u0131\u011f\u0131 bir form\u00fcl se\u00e7in. Laboratuvar \u00f6l\u00e7e\u011finde yan yana bir test yap\u0131n. \u00c7o\u011fu ki\u015fi, MADG ile \u0131slak gran\u00fclasyon aras\u0131nda tablet kalitesinin ne kadar benzer oldu\u011funa ve bunun i\u015fleme s\u00fcresinin sadece bir k\u0131sm\u0131n\u0131 gerektirdi\u011fine \u015fa\u015f\u0131r\u0131r.<\/p>

    \u0130lk partilerinizi k\u00fc\u00e7\u00fck tutun. 2 litrelik bir y\u00fcksek kesme kuvvetli gran\u00fclat\u00f6r, erken a\u015famadaki geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131 i\u00e7in fazlas\u0131yla yeterlidir. Su seviyesini ve p\u00fcsk\u00fcrtme oran\u0131n\u0131 kesin olarak belirledikten sonra, daha sonra \u00fcretim \u00f6l\u00e7e\u011fini b\u00fcy\u00fctebilirsiniz.<\/p>

    Emme a\u015famas\u0131nda nem i\u00e7eri\u011fini yak\u0131ndan takip edin. MCC ve silika ilave edildikten sonra yap\u0131lacak bir kurutma kayb\u0131 testi, gran\u00fclasyonun ger\u00e7ekten kuru olup olmad\u0131\u011f\u0131n\u0131 veya emici seviyelerini ayarlaman\u0131z gerekip gerekmedi\u011fini size g\u00f6sterecektir. Islak gran\u00fclasyon i\u015fleminde kurutma sonras\u0131nda hedefledi\u011finiz de\u011fere uygun bir nihai nem i\u00e7eri\u011fi hedefleyin; bu de\u011fer genellikle 2%'nin alt\u0131ndad\u0131r.<\/p>

    Her \u015feyi belgelendirin. P\u00fcsk\u00fcrtme h\u0131z\u0131, pervane h\u0131z\u0131, su miktar\u0131, katk\u0131 maddelerinin eklenme s\u0131ras\u0131, kar\u0131\u015ft\u0131rma s\u00fcreleri. MADG, \u0131slak gran\u00fclasyona k\u0131yasla daha az de\u011fi\u015fken i\u00e7erir; bu bir avantajd\u0131r. Ancak bu, her bir de\u011fi\u015fkenin sonu\u00e7 \u00fczerinde daha b\u00fcy\u00fck bir etkiye sahip oldu\u011fu anlam\u0131na da gelir. Su miktar\u0131nda meydana gelen k\u00fc\u00e7\u00fck de\u011fi\u015fiklikler, gran\u00fcl boyutunuzu \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015ftirebilir.<\/p>

    \u00c7\u00f6z\u00fcm<\/b><\/strong><\/h2>

    MADG yeni bir teknoloji de\u011fildir. G\u00f6ze \u00e7arpan bir \u015fey de de\u011fildir. Ancak do\u011fru form\u00fcl kullan\u0131ld\u0131\u011f\u0131nda, \u00fcretim s\u00fcrecinizden saatler kazand\u0131r\u0131r, enerji tasarrufu sa\u011flar ve kat\u0131 tabletlere preslenebilen gran\u00fcller elde etmenizi sa\u011flar. \u0130la\u00e7 sekt\u00f6r\u00fc de\u011fi\u015fim konusunda yava\u015f hareket eder, ancak bu konudaki say\u0131sal veriler art\u0131k daha fazla tart\u0131\u015fmaya yer b\u0131rakm\u0131yor.<\/p>

    Referanslar:<\/strong><\/h2>

    Nemle aktive olan kuru gran\u00fclasyondan daha fazla verim al\u0131n<\/strong><\/em><\/span><\/a>.<\/p>

    SeDeM diyagram\u0131n\u0131n yard\u0131m\u0131yla mide i\u00e7inde uzun s\u00fcre kalabilen tabletlerin geli\u015ftirilmesi amac\u0131yla nemle etkinle\u015fen kuru gran\u00fclasyon y\u00f6nteminin incelenmesi<\/strong><\/em><\/span><\/a>.<\/p>

    \u0130la\u00e7 End\u00fcstrisinde Islak Gran\u00fclasyon S\u00fcreci K\u0131lavuzu.<\/strong><\/em><\/span><\/a><\/p>

    Telif Hakk\u0131 Uyar\u0131s\u0131:<\/b><\/h2>

    Finetech Group'un \u00f6nceden a\u00e7\u0131k yaz\u0131l\u0131 onay\u0131 olmadan bu web sitesindeki herhangi bir i\u00e7eri\u011fi \u00e7o\u011faltamaz, de\u011fi\u015ftiremez, yay\u0131nlayamaz, g\u00f6r\u00fcnt\u00fcleyemez, iletemez veya herhangi bir \u015fekilde istismar edemezsiniz veya bu t\u00fcr i\u00e7eri\u011fi herhangi bir veritaban\u0131 olu\u015fturmak i\u00e7in kullanamazs\u0131n\u0131z. \u0130\u00e7eri\u011fi kullanma izni i\u00e7in l\u00fctfen ileti\u015fime ge\u00e7in: info@pharmamachinecn.com<\/span><\/a><\/p>

    Yasal Uyar\u0131:<\/b><\/h2>

    Bu makalede yer alan bilgiler yaln\u0131zca genel bilgilendirme ama\u00e7l\u0131d\u0131r. \u015eirket, herhangi bir bilginin do\u011frulu\u011funu, g\u00fcncelli\u011fini veya eksiksizli\u011fini garanti etmez ve \u015eirket, bu makalenin i\u00e7eri\u011findeki hatalar veya eksiklikler i\u00e7in hi\u00e7bir sorumluluk kabul etmez.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

    Wet granulation has been the go-to for tablet making as long as most of us can remember. You mix your […]<\/p>\n","protected":false},"author":1,"featured_media":18501,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[83],"tags":[],"class_list":["post-18354","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-granulation-equipment"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts\/18354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/comments?post=18354"}],"version-history":[{"count":1,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts\/18354\/revisions"}],"predecessor-version":[{"id":22831,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts\/18354\/revisions\/22831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/media\/18501"}],"wp:attachment":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/media?parent=18354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/categories?post=18354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/tags?post=18354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}