{"id":19353,"date":"2026-09-30T00:44:44","date_gmt":"2026-09-30T00:44:44","guid":{"rendered":"https:\/\/pharmamachinecn.com\/?p=19353"},"modified":"2026-06-23T00:57:34","modified_gmt":"2026-06-23T00:57:34","slug":"pharmaceutical-raw-material-manufacturers","status":"publish","type":"post","link":"https:\/\/pharmamachinecn.com\/tr\/pharmaceutical-raw-material-manufacturers\/","title":{"rendered":"En \u0130yi 10 \u0130la\u00e7 Hammaddesi \u00dcreticisi"},"content":{"rendered":"
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T\u0131p, ila\u00e7lar\u0131 g\u00fcvenli ve etkili k\u0131lan hammaddelere ba\u011fl\u0131d\u0131r. Bu temel malzemeleri sekt\u00f6re tedarik eden birka\u00e7 \u015firket \u00f6ne \u00e7\u0131kmaktad\u0131r. Bu \u015firketlerin \u00e7al\u0131\u015fmalar\u0131, yayg\u0131n olarak kullan\u0131lan tabletlerden yeni ve geli\u015fmi\u015f tedavilere kadar her \u015feyi desteklemektedir.<\/p>

\"\u00c7in'den
\u00c7in'den \u0130la\u00e7 Hammaddesi \u00dcreticisi.<\/strong><\/em><\/figcaption><\/figure>
\u015eirket<\/b><\/strong><\/td>Kurulu\u015f Y\u0131l\u0131<\/b><\/strong><\/td>\u00dclke<\/b><\/strong><\/td><\/tr>
BASF<\/td>1865<\/td>Almanya<\/td><\/tr>
Merck KGaA<\/td>1668<\/td>Almanya<\/td><\/tr>
Evonik Industries<\/td>2007<\/td>Almanya<\/td><\/tr>
Ashland<\/td>1924<\/td>Amerika Birle\u015fik Devletleri<\/td><\/tr>
Roquette<\/td>1933<\/td>Fransa<\/td><\/tr>
Colorcon<\/td>1961<\/td>Amerika Birle\u015fik Devletleri<\/td><\/tr>
DFE Pharma<\/td>2006<\/td>Almanya<\/td><\/tr>
JRS Pharma<\/td>1878<\/td>Almanya<\/td><\/tr>
Lubrizol<\/td>1928<\/td>Amerika Birle\u015fik Devletleri<\/td><\/tr>
Croda International<\/td>1925<\/td>Birle\u015fik Krall\u0131k<\/td><\/tr><\/tbody><\/table><\/div>

BASF<\/strong><\/h2>

Kurulu\u015f Y\u0131l\u0131: 1865<\/strong><\/p>

Ana \u00dcr\u00fcnler:<\/strong><\/h3>
  • An\u0131nda ve Modifiye Sal\u0131ml\u0131 Polimerler (Kollidon\u00ae, Kollicoat\u00ae).<\/strong><\/li>
  • \u00c7\u00f6z\u00fcnd\u00fcr\u00fcc\u00fcler ve Em\u00fclgat\u00f6rler (Kolliphor\u00ae, Soluplus\u00ae).<\/strong><\/li>
  • S\u00fcper par\u00e7alay\u0131c\u0131lar (Kollidon\u00ae CL).<\/strong><\/li>
  • Aktif \u0130la\u00e7 Bile\u015fenleri (\u0130buprofen, Dekspantenol).<\/strong><\/li>
  • Y\u00fcksek safl\u0131kta Omega-3 ya\u011f asitleri.<\/strong><\/li>
  • \u00c7e\u015fitli uygulamalara y\u00f6nelik povidonlar (PVP).<\/strong><\/li><\/ul>

    BASF, Almanya men\u015feli dev bir kimya \u015firketidir. Ana merkezi Ludwigshafen adl\u0131 \u015fehirde bulunmaktad\u0131r. \u015eirket, uzun zaman \u00f6nce Friedrich Engelhorn taraf\u0131ndan kurulmu\u015ftur.<\/p>

    Her t\u00fcrl\u00fc kimyasal madde \u00fcretiyorlar. Ancak i\u015flerinin en \u00f6nemli k\u0131sm\u0131, ila\u00e7lar i\u00e7in gerekli hammaddeleri \u00fcretmektir. Bu \u00e7ok \u00f6nemli bir i\u015ftir.<\/p>

    Yani bir ilaca bakt\u0131\u011f\u0131n\u0131zda, asl\u0131nda iki t\u00fcr bile\u015feni oldu\u011funu g\u00f6r\u00fcrs\u00fcn\u00fcz. V\u00fccudunuzu ger\u00e7ekten etkileyen aktif madde vard\u0131r. Buna API denir.<\/p>

    Bir de geri kalan her \u015fey var. Di\u011fer t\u00fcm maddeler \u201cyard\u0131mc\u0131 madde\u201d olarak adland\u0131r\u0131l\u0131r. Bunlar, hap\u0131 bir arada tutan ve do\u011fru \u015fekilde etki etmesine yard\u0131mc\u0131 olan destekleyici bile\u015fenlerdir. BASF, hem aktif ila\u00e7 maddeleri (API) hem de yard\u0131mc\u0131 maddeler \u00fcretmektedir.<\/p>

    Kollidon\u00ae markas\u0131, ila\u00e7 \u00fcretim d\u00fcnyas\u0131nda olduk\u00e7a \u00fcnl\u00fcd\u00fcr. Bunlar, birbirine z\u0131t i\u015flevler g\u00f6rebilen \u00f6zel uzun molek\u00fcllerdir. Baz\u0131lar\u0131, tabletin ufalanmas\u0131n\u0131 \u00f6nlemek i\u00e7in g\u00fc\u00e7l\u00fc bir yap\u0131\u015ft\u0131r\u0131c\u0131 g\u00f6revi g\u00f6r\u00fcr. Di\u011ferleri ise tabletin midenizde \u00e7ok h\u0131zl\u0131 bir \u015fekilde par\u00e7alanmas\u0131na yard\u0131mc\u0131 olmak \u00fczere tasarlanm\u0131\u015ft\u0131r.<\/p>

    Ayr\u0131ca ba\u015fka ak\u0131ll\u0131 bile\u015fenler de \u00fcretiyorlar. Kolliphor\u00ae markal\u0131 \u00fcr\u00fcnleri, ila\u00e7lar\u0131n suda \u00e7\u00f6z\u00fcnmesine yard\u0131mc\u0131 oluyor. Bu \u00e7ok \u00f6nemli bir konu; \u00e7\u00fcnk\u00fc bir ila\u00e7 \u00e7\u00f6z\u00fcnmezse, v\u00fccudunuz onu kullanamaz.<\/p>

    Merck KGaA<\/strong><\/h2>

    Kurulu\u015f Y\u0131l\u0131: 1668<\/strong><\/p>

    Ana \u00dcr\u00fcnler:<\/strong><\/h3>
    • Kat\u0131 ve S\u0131v\u0131 \u0130la\u00e7 Formlar\u0131 i\u00e7in Yard\u0131mc\u0131 Maddeler (Parteck\u00ae, EMDOPRESS\u00ae).<\/strong><\/li>
    • Aktif \u0130la\u00e7 Maddesi (API) Sentezi i\u00e7in Y\u00fcksek Safl\u0131kta \u00c7\u00f6z\u00fcc\u00fcler ve Tuzlar.<\/strong><\/li>
    • H\u00fccre K\u00fclt\u00fcr\u00fc Ortamlar\u0131, Besin Maddeleri ve Takviyeler (CHOZN\u00ae, EX-CELL\u00ae).<\/strong><\/li>
    • Safla\u015ft\u0131rma i\u00e7in Kromatografi Ortamlar\u0131 (Eshmuno\u00ae, Fractogel\u00ae).<\/strong><\/li>
    • Tek Kullan\u0131ml\u0131k \u00dcretim Sistemleri (Mobius\u00ae).<\/strong><\/li>
    • Steril \u0130\u015fleme i\u00e7in Filtreleme \u00dcr\u00fcnleri (Millipore\u00ae).<\/strong><\/li>
    • Aktif Farmas\u00f6tik Bile\u015fenler ve \u0130la\u00e7 Da\u011f\u0131t\u0131m Bile\u015fikleri (Lipidler).<\/strong><\/li><\/ul>

      Merck KGaA, d\u00fcnyan\u0131n en eski ila\u00e7 ve kimya \u015firketidir. Cidden, \u00e7ok uzun zamand\u0131r var. Merkezi Almanya\u2019da bulunan \u015firket, Friedrich Jacob Merck taraf\u0131ndan tek bir eczane olarak kuruldu.<\/p>

      \u015eimdi, bu durum biraz kafa kar\u0131\u015ft\u0131r\u0131c\u0131 olabilir. Bu Alman \u015firketi, Merck & Co. adl\u0131 Amerikan \u015firketinden tamamen ayr\u0131d\u0131r. Eskiden birbirleriyle ba\u011flant\u0131l\u0131yd\u0131lar, ancak art\u0131k de\u011fil. Yani bunlar iki farkl\u0131 \u015firkettir.<\/p>

      \u015eirketler normal haplar \u00fcrettiklerinde \u00e7ok say\u0131da temel maddeye ihtiya\u00e7 duyarlar. Merck KGaA bu maddeleri temin eder. Bunlar aras\u0131nda, tozu hap haline getirmek i\u00e7in gerekli olan ve \u201cyard\u0131mc\u0131 madde\u201d olarak adland\u0131r\u0131lan t\u00fcm bile\u015fenler yer al\u0131r.<\/p>

      Ayr\u0131ca, aktif ilac\u0131n \u00fcretimi i\u00e7in kullan\u0131lan s\u00fcper saf kimyasallar\u0131 ve s\u0131v\u0131lar\u0131 da sat\u0131yorlar. Bu malzemelerin inan\u0131lmaz derecede temiz olmas\u0131 gerekiyor. Herhangi bir kir veya yabanc\u0131 madde ilac\u0131 bozabilir.<\/p>

      \u015eirket ayr\u0131ca, biyofarmas\u00f6tikler olarak adland\u0131r\u0131lan yeni bir ila\u00e7 t\u00fcr\u00fcn\u00fcn \u00fcretiminde de \u00f6nemli bir rol oynamaktad\u0131r. Bu ila\u00e7lar canl\u0131 h\u00fccreler taraf\u0131ndan \u00fcretilmektedir.<\/p>

      \u00d6ncelikle, h\u00fccreleri \u00e7o\u011faltman\u0131z gerekir. Buna \u201c\u00f6n i\u015flem\u201d denir. \u015eirket, h\u00fccrelerin ya\u015famas\u0131 ve \u00e7o\u011falmas\u0131 i\u00e7in gerekli olan \u201ch\u00fccre k\u00fclt\u00fcr\u00fc besiyeri\u201d ad\u0131 verilen \u00f6zel s\u0131v\u0131 besin maddesini satmaktad\u0131r.<\/p>

      Ard\u0131ndan, h\u00fccreler ilac\u0131 \u00fcrettikten sonra, onu ar\u0131tmak gerekir. Buna \u201cson a\u015fama\u201d denir. \u015eirket, saf ilac\u0131 t\u00fcm at\u0131klardan ay\u0131rmak i\u00e7in kullan\u0131lan geli\u015fmi\u015f filtreleri ve ara\u00e7lar\u0131 \u00fcretmektedir.<\/p>

      Bu son ad\u0131m son derece \u00f6nemlidir. Bu ad\u0131m, nihai ilac\u0131n insanlar taraf\u0131ndan g\u00fcvenle kullan\u0131labilmesini sa\u011flar.<\/p>

      Evonik Industries<\/strong><\/h2>

      Kurulu\u015f Y\u0131l\u0131: 2007<\/strong><\/p>

      Ana \u00dcr\u00fcnler:<\/strong><\/h3>
      • A\u011f\u0131zdan Al\u0131nan Modifiye Sal\u0131ml\u0131 Polimerler ve Kaplamalar (EUDRAGIT\u00ae).<\/strong><\/li>
      • Parenteral Uygulama i\u00e7in Biyolojik Olarak Emilebilir Polimerler (RESOMER\u00ae).<\/strong><\/li>
      • LNP Form\u00fclasyonlar\u0131 i\u00e7in Lipidler.<\/strong><\/li>
      • \u0130nf\u00fczyon i\u00e7in Y\u00fcksek Safl\u0131kta Amino Asitler.<\/strong><\/li>
      • \u00d6zel H\u00fccre K\u00fclt\u00fcr\u00fc Ortamlar\u0131 Bile\u015fenleri (cQrex\u00ae).<\/strong><\/li>
      • Karma\u015f\u0131k aktif ila\u00e7 bile\u015fenlerinin (API) fason \u00fcretimi.<\/strong><\/li><\/ul>

        Evonik Industries, Almanya\u2019n\u0131n Essen kentinde bulunan bir \u00f6zel kimya \u015firketidir. \u015eirketin Sa\u011fl\u0131k Hizmetleri grubu, ila\u00e7 end\u00fcstrisi i\u00e7in geli\u015fmi\u015f malzemeler \u00fcretme konusunda lider konumdad\u0131r. \u0130la\u00e7lar\u0131 v\u00fccut i\u00e7ine ula\u015ft\u0131rmak i\u00e7in ak\u0131ll\u0131 y\u00f6ntemler geli\u015ftirme konusunda ger\u00e7ekten \u00e7ok ba\u015far\u0131l\u0131d\u0131rlar.<\/p>

        En \u00fcnl\u00fc \u00fcr\u00fcnleri EUDRAGIT\u00ae ad\u0131n\u0131 ta\u015f\u0131yor. Bu, haplar\u0131n \u00fczerine \u00f6zel kaplamalar uygulamak i\u00e7in kullan\u0131lan bir dizi bile\u015fendir. Bu kaplama sadece renk vermek i\u00e7in de\u011fildir. Asl\u0131nda hapa ne yapmas\u0131 gerekti\u011fini s\u00f6yler.<\/p>

        \u00d6rne\u011fin, bir kaplama, bir hap\u0131 mide asidinden koruyabilir. Hap, mideden g\u00fcvenli bir \u015fekilde ge\u00e7er. Ancak ba\u011f\u0131rsaklara ula\u015ft\u0131\u011f\u0131nda \u00e7\u00f6z\u00fcnmeye ve ilac\u0131n\u0131 salmaya ba\u015flar. Di\u011fer kaplamalar ise hap\u0131n ilac\u0131n\u0131 g\u00fcn boyu yava\u015f\u00e7a salmas\u0131n\u0131 sa\u011flar.<\/p>

        Evonik ayr\u0131ca enjeksiyon yoluyla uygulanan veya v\u00fccuda yerle\u015ftirilen ila\u00e7lar i\u00e7in malzemeler \u00fcretmektedir. \u015eirketin RESOMER\u00ae markas\u0131, zamanla v\u00fccut i\u00e7inde g\u00fcvenli bir \u015fekilde \u00e7\u00f6z\u00fcnen bir polimer serisidir. Bu malzemeler, kemik iyile\u015ftikten sonra v\u00fccuttan tamamen kaybolan t\u0131bbi vidalar\u0131n \u00fcretiminde kullan\u0131labilir. Ya da aylarca ila\u00e7 salan enjeksiyonlarda da kullan\u0131labilirler.<\/p>

        Ashland<\/strong><\/h2>

        Kurulu\u015f Y\u0131l\u0131: 1924<\/strong><\/p>

        Ana \u00dcr\u00fcnler:<\/strong><\/h3>
        • Tablet Ba\u011flay\u0131c\u0131lar (Plasdone\u2122, Benecel\u2122).<\/strong><\/li>
        • S\u00fcper par\u00e7alay\u0131c\u0131lar (Polyplasdone\u2122).<\/strong><\/li>
        • Kontroll\u00fc Sal\u0131m Matris Olu\u015fturucular (Benecel\u2122 HPMC).<\/strong><\/li>
        • Film Kaplamalar (Aquarius\u2122, Klucel\u2122 HPC).<\/strong><\/li>
        • \u00c7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fc Art\u0131r\u0131c\u0131 Polimerler (PVPs, VAZOLVE\u2122).<\/strong><\/li><\/ul>

          Ashland, Delaware eyaletinin Wilmington kentinde bulunan bir Amerikan \u015firketidir. \u015eirket, \u00f6zel malzemeler \u00fcretmektedir. Yapt\u0131klar\u0131 i\u015fler sayesinde t\u0131p d\u00fcnyas\u0131nda olduk\u00e7a sayg\u0131n bir yere sahiptir.<\/p>

          \u00d6zel uzun zincirli molek\u00fcller olan polimerlerin \u00fcretiminde uzmanlar. Kulland\u0131klar\u0131 bile\u015fenlerin \u00e7o\u011fu asl\u0131nda odun hamuru gibi do\u011fal kaynaklardan elde ediliyor. Bu polimerler, tablet ve kaps\u00fcllerde \u00f6nemli yard\u0131mc\u0131 bile\u015fenler olarak kullan\u0131l\u0131yor.<\/p>

          Klucel\u2122 ve Benecel\u2122 gibi \u00fcr\u00fcnleri her zaman kullan\u0131lmaktad\u0131r. Bu maddelerin temel i\u015flevlerinden biri \u201cba\u011flay\u0131c\u0131\u201d olarak g\u00f6rev yapmakt\u0131r. Ba\u011flay\u0131c\u0131, yap\u0131\u015ft\u0131r\u0131c\u0131 gibi i\u015flev g\u00f6r\u00fcr. Hap i\u00e7indeki t\u00fcm toz halindeki bile\u015fenleri bir arada tutarak sert ve kat\u0131 bir tablet haline gelmesini sa\u011flar.<\/p>

          \u015eirketin bir di\u011fer \u00f6nemli \u00fcr\u00fcn\u00fc ise Polyplasdone\u2122\u201cdur. Bu madde, \u201ds\u00fcper par\u00e7alay\u0131c\u0131\u201d olarak bilinir. Bir par\u00e7alay\u0131c\u0131n\u0131n g\u00f6revi, tableti yuttuktan sonra par\u00e7alanmas\u0131na yard\u0131mc\u0131 olmakt\u0131r. Bu madde ise bu i\u015fi son derece h\u0131zl\u0131 bir \u015fekilde yerine getirir.<\/p>

          Island\u0131\u011f\u0131nda tabletin neredeyse an\u0131nda ufalanmas\u0131na neden olur. Bu, etkisini hemen g\u00f6stermesi gereken ila\u00e7lar i\u00e7in ger\u00e7ekten \u00e7ok \u00f6nemlidir.<\/p>

          Ashland, bir ba\u015fka b\u00fcy\u00fck sorunun \u00e7\u00f6z\u00fcm\u00fcne de katk\u0131da bulunuyor. Baz\u0131 ila\u00e7lar\u0131n suda \u00e7\u00f6z\u00fcnmesi ger\u00e7ekten zordur. \u0130la\u00e7 \u00e7\u00f6z\u00fcnmezse, v\u00fccudunuz onu kullanamaz. Ashland, bu \u00e7\u00f6z\u00fcnmesi zor ila\u00e7lar\u0131n d\u00fczg\u00fcn bir \u015fekilde \u00e7\u00f6z\u00fcnmesine yard\u0131mc\u0131 olan \u00f6zel bile\u015fenler \u00fcreterek ilac\u0131n daha etkili olmas\u0131n\u0131 sa\u011fl\u0131yor.<\/p>

          Roquette<\/strong><\/h2>

          Kurulu\u015f Y\u0131l\u0131: 1933<\/strong><\/p>

          Ana \u00dcr\u00fcnler:<\/strong><\/h3>
          • Do\u011frudan S\u0131k\u0131\u015ft\u0131rma Dolgu Maddeleri ve Ba\u011flay\u0131c\u0131lar (PEARLITOL\u00ae Mannitol, LYCATAB\u00ae Ni\u015fasta).<\/strong><\/li>
          • Islak Gran\u00fclasyon Ba\u011flay\u0131c\u0131lar\u0131.<\/strong><\/li>
          • Enjeksiyonluk Karbonhidratlar.<\/strong><\/li>
          • \u00c7\u00f6z\u00fcn\u00fcrl\u00fck Art\u0131r\u0131c\u0131lar (KLEPTOSE\u00ae Hidroksipropil Betadex).<\/strong><\/li>
          • A\u011f\u0131zda Kullan\u0131lan S\u0131v\u0131 Tatland\u0131r\u0131c\u0131lar ve Ta\u015f\u0131y\u0131c\u0131 Maddeler (NEOSORB\u00ae Sorbitol).<\/strong><\/li>
          • Bitki kaynakl\u0131 aktif ila\u00e7 maddeleri (\u00f6rn. kersetin).<\/strong><\/li><\/ul>

            Roquette, Roquette karde\u015fler taraf\u0131ndan kurulan bir Frans\u0131z \u015firketidir. Bir aile \u015firketidir. Bitkilerden elde edilen bile\u015fenlerin \u00fcretiminde d\u00fcnya \u00e7ap\u0131nda lider konumdad\u0131r.<\/p>

            M\u0131s\u0131r, bu\u011fday ve patates gibi hammaddeleri kullan\u0131yorlar. Ard\u0131ndan bunlar\u0131 ila\u00e7 end\u00fcstrisi i\u00e7in y\u00fcksek kaliteli yard\u0131mc\u0131 bile\u015fenlere d\u00f6n\u00fc\u015ft\u00fcr\u00fcyorlar.<\/p>

            Bu \u015firketin uzmanl\u0131k alan\u0131 \u015feker ve ni\u015fastalar\u0131n i\u015flenmesidir. Bunlar\u0131 ila\u00e7 \u00fcretiminde kullan\u0131lan fonksiyonel bile\u015fenlere d\u00f6n\u00fc\u015ft\u00fcr\u00fcrler. \u00d6rne\u011fin, PEARLITOL\u00ae adl\u0131 mannitol \u00fcr\u00fcnleri, tabletler i\u00e7in yayg\u0131n olarak kullan\u0131lan bir dolgu maddesidir. Dolgu maddesi, hap\u0131n hacmini art\u0131r\u0131r.<\/p>

            Mannitol, \u00e7i\u011fnenebilir veya a\u011f\u0131zda eriyen tabletler i\u00e7in ger\u00e7ekten \u00e7ok uygundur. Bunun nedeni, hafif tatl\u0131 bir tada sahip olmas\u0131 ve erirken ho\u015f, serinletici bir his vermesidir. Ayr\u0131ca, \u00f6ks\u00fcr\u00fck \u015furubu gibi s\u0131v\u0131 ila\u00e7lar\u0131 tatland\u0131rmak i\u00e7in kullan\u0131lan NEOSORB\u00ae sorbitol de \u00fcretilmektedir.<\/p>

            LYCATAB\u00ae markal\u0131 \u00fcr\u00fcn, ayn\u0131 anda iki i\u015flevi birden yerine getiren \u00f6zel bir ni\u015fastad\u0131r. Tabletin bir arada kalmas\u0131na yard\u0131mc\u0131 olurken, ayn\u0131 zamanda tabletin par\u00e7alanmas\u0131na da katk\u0131da bulunur. Tek bir bile\u015fenin iki i\u015flevi birden yerine getirmesi, ila\u00e7 \u00fcreticileri i\u00e7in i\u015fleri \u00e7ok daha kolayla\u015ft\u0131rabilir.<\/p>

            Colorcon<\/strong><\/h2>

            Kurulu\u015f Y\u0131l\u0131: 1961<\/strong><\/p>

            Ana \u00dcr\u00fcnler:<\/strong><\/h3>
            • H\u0131zl\u0131 Sal\u0131ml\u0131 Film Kaplamalar (Opadry\u00ae).<\/strong><\/li>
            • Enterik ve Uzun Etkili Kaplamalar (Acryl-EZE\u00ae, Surelease\u00ae).<\/strong><\/li>
            • \u00d6zel Yard\u0131mc\u0131 Maddeler (Starch 1500\u00ae, Suglets\u00ae).<\/strong><\/li>
            • \u00c7\u00f6z\u00fcn\u00fcrl\u00fck i\u00e7in Form\u00fclasyon Teknolojileri (Opadry\u00ae Sol).<\/strong><\/li>
            • Markalama i\u00e7in Yenilebilir M\u00fcrekkepler (Opacode\u00ae).<\/strong><\/li><\/ul>

              Colorcon, Pennsylvania merkezli bir Amerikan \u015firketidir. \u015eirket, John J. Stanek taraf\u0131ndan kurulmu\u015ftur. \u015eirketin t\u00fcm faaliyetleri tek bir b\u00fcy\u00fck fikre odaklanm\u0131\u015ft\u0131r: hap \u00fcretimini kolayla\u015ft\u0131rmak.<\/p>

              Kullan\u0131ma haz\u0131r film kaplama sistemleriyle tan\u0131n\u0131rlar. Bir hap\u0131n \u00fczerine kaplama uygulamak zorlu bir s\u00fcre\u00e7 olabilir. Birka\u00e7 bile\u015feni tam do\u011fru oranda kar\u0131\u015ft\u0131rmak gerekir.<\/p>

              Colorcon, bu sorunu ana \u00fcr\u00fcn\u00fc olan Opadry\u00ae ile \u00e7\u00f6zd\u00fc. Bu, sadece tek bir bile\u015fen de\u011fildir. Kaplama i\u00e7in gerekli olan her \u015feyin \u00f6nceden kar\u0131\u015ft\u0131r\u0131lm\u0131\u015f halde bulundu\u011fu bir torba tozdur. Polimer, plastikle\u015ftirici ve renklendirici hepsi bu torbada mevcuttur.<\/p>

              Bir ila\u00e7 \u015firketi, toza sadece su eklemekle yetinir. Bu, onlara \u00e7ok fazla zaman kazand\u0131r\u0131r ve hatalar\u0131n \u00f6nlenmesine yard\u0131mc\u0131 olur.<\/p>

              Bu, ila\u00e7 \u00fcretim s\u00fcrecinin tamam\u0131n\u0131 \u00e7ok daha verimli hale getirir. Her bir hap\u0131n tutarl\u0131 ve y\u00fcksek kalitede olmas\u0131n\u0131 sa\u011flamaya yard\u0131mc\u0131 olur.<\/p>

              Kaplamalar\u0131n birka\u00e7 i\u015flevi vard\u0131r. Renk, insanlar\u0131n ila\u00e7lar\u0131n\u0131 birbirinden ay\u0131rt etmelerine yard\u0131mc\u0131 olur. Kaplama ayr\u0131ca hap\u0131 p\u00fcr\u00fczs\u00fcz hale getirerek yutmay\u0131 kolayla\u015ft\u0131r\u0131r. Ayr\u0131ca i\u00e7indeki ilac\u0131 nemden koruyabilir.<\/p>

              Basit kaplamalar\u0131n \u00f6tesinde, daha karma\u015f\u0131k haplar i\u00e7in sistemler de \u00fcretmektedirler. Di\u011fer \u00fcr\u00fcnleri ise ilac\u0131 uzun bir s\u00fcre boyunca yava\u015f\u00e7a salan kaplamalar olu\u015fturmak i\u00e7in kullan\u0131lmaktad\u0131r.<\/p>

              DFE Pharma<\/strong><\/h2>

              Kurulu\u015f Y\u0131l\u0131: 2006<\/strong><\/p>

              Ana \u00dcr\u00fcnler:<\/strong><\/h3>
              • Islak Gran\u00fclasyon i\u00e7in \u00d6\u011f\u00fct\u00fclm\u00fc\u015f ve Eleklenmi\u015f Laktoz (Pharmatose\u00ae).<\/strong><\/li>
              • Do\u011frudan S\u0131k\u0131\u015ft\u0131rma i\u00e7in P\u00fcsk\u00fcrtmeyle Kurutulmu\u015f Laktoz (SuperTab\u00ae).<\/strong><\/li>
              • Kuru Toz \u0130nhalasyon i\u00e7in Laktoz Ta\u015f\u0131y\u0131c\u0131 (Lactohale\u00ae).<\/strong><\/li>
              • Mikrokristalin Sel\u00fcloz Ba\u011flay\u0131c\u0131lar\/Dolgu Maddeleri (Pharmacel\u00ae).<\/strong><\/li>
              • S\u00fcper par\u00e7alay\u0131c\u0131lar (Primojel\u00ae, Primellose\u00ae).<\/strong><\/li><\/ul>

                DFE Pharma, ila\u00e7 yard\u0131mc\u0131 maddeleri alan\u0131nda d\u00fcnyan\u0131n \u00f6nde gelen \u015firketlerinden biridir. Merkezi Almanya\u2019n\u0131n Goch kentindedir. \u015eirket, d\u00fcnyan\u0131n en b\u00fcy\u00fck iki s\u00fct \u00fcr\u00fcnleri \u015firketi aras\u0131ndaki bir proje olarak kurulmu\u015ftur.<\/p>

                Bu ge\u00e7mi\u015fleri, onlar\u0131 ana \u00fcr\u00fcnleri olan laktoz konusunda tam anlam\u0131yla uzmanlar haline getiriyor. Laktoz, s\u00fctte bulunan do\u011fal bir \u015feker t\u00fcr\u00fcd\u00fcr.<\/p>

                T\u0131p d\u00fcnyas\u0131nda laktoz, en yayg\u0131n yard\u0131mc\u0131 maddelerden biridir. Esas olarak tabletlere hacim kazand\u0131rmak i\u00e7in dolgu maddesi olarak kullan\u0131l\u0131r. Ayr\u0131ca, tozun s\u0131k\u0131\u015ft\u0131r\u0131larak kat\u0131 bir hap haline getirilmesine yard\u0131mc\u0131 olan bir ba\u011flay\u0131c\u0131d\u0131r.<\/p>

                Piyasada pek \u00e7ok farkl\u0131 t\u00fcrde laktoz sat\u0131lmaktad\u0131r. Her biri, tablet \u00fcretiminin belirli bir y\u00f6ntemi i\u00e7in tasarlanm\u0131\u015ft\u0131r. Bu sayede ila\u00e7 \u015firketleri, ekipmanlar\u0131na en uygun kaliteyi se\u00e7ebilmektedir.<\/p>

                Ancak ayn\u0131 zamanda inhalerler i\u00e7in \u00e7ok \u00f6zel bir laktoz t\u00fcr\u00fc de \u00fcretiyorlar. Lactohale\u00ae adl\u0131 \u00fcr\u00fcnleri, \u00e7ok ince par\u00e7ac\u0131klardan olu\u015fur. Inhalerde bu minik laktoz par\u00e7ac\u0131klar\u0131, kendilerinden de daha k\u00fc\u00e7\u00fck olan ila\u00e7 par\u00e7ac\u0131klar\u0131n\u0131 ta\u015f\u0131r. Bu sayede ilac\u0131n, gitmesi gereken yere, yani ki\u015finin akci\u011ferlerinin derinliklerine ula\u015fmas\u0131na yard\u0131mc\u0131 olur.<\/p>

                JRS Pharma<\/strong><\/h2>

                Kurulu\u015f Y\u0131l\u0131: 1878<\/strong><\/p>

                Ana \u00dcr\u00fcnler:<\/strong><\/h3>
                • Mikrokristalin Sel\u00fcloz (VIVAPUR\u00ae, EMCOCEL\u00ae).<\/strong><\/li>
                • Y\u00fcksek \u0130\u015flevselli\u011fe Sahip Birlikte \u0130\u015flenmi\u015f Yard\u0131mc\u0131 Maddeler (PROSOLV\u00ae SMCC, PROSOLV\u00ae EASYtab).<\/strong><\/li>
                • S\u00fcper par\u00e7alay\u0131c\u0131lar (EXPLOTAB\u00ae, VIVASOL\u00ae).<\/strong><\/li>
                • Sodyum Ni\u015fasta Glikolat ve HPMC gibi ba\u011flay\u0131c\u0131lar.<\/strong><\/li>
                • Do\u011fal Lifli Yard\u0131mc\u0131 Maddeler (VITACEL\u00ae).<\/strong><\/li>
                • Kalsiyum Fosfatlar ve S\u0131k\u0131\u015ft\u0131r\u0131labilir \u015eekerler.<\/strong><\/li>
                • Kullan\u0131ma haz\u0131r film kaplamalar (VIVACOAT\u00ae).<\/strong><\/li><\/ul>

                  JRS Pharma, J. Rettenmaier & S\u00f6hne adl\u0131 Alman \u015firketinin ila\u00e7 b\u00f6l\u00fcm\u00fcd\u00fcr. Bu bir aile \u015firketidir. \u015eirket, odun hamuru gibi kaynaklardan elde edilen do\u011fal liflerle \u00e7al\u0131\u015fma konusunda uzun bir ge\u00e7mi\u015fe sahiptir.<\/p>

                  Bu bilgi birikimini, organik hammaddelerden ila\u00e7 bile\u015fenleri \u00fcretme alan\u0131nda d\u00fcnya lideri olmak i\u00e7in kulland\u0131lar.<\/p>

                  En \u00f6nemli \u00fcr\u00fcnleri mikrokristalin sel\u00fcloz, yani MCC\u2019dir. Bu, d\u00fcnyadaki en \u00f6nemli ve kullan\u0131\u015fl\u0131 yard\u0131mc\u0131 maddelerden biridir. Tablet \u00fcreten hemen hemen her \u015firket bunu kullanmaktad\u0131r.<\/p>

                  MCC, ger\u00e7ek anlamda \u00e7ok i\u015flevli bir maddedir. Tablet bile\u015fenlerini birbirine ba\u011flayarak hap\u0131n sa\u011flam olmas\u0131n\u0131 sa\u011flar. Hacim kazand\u0131r\u0131r. Ayr\u0131ca, tableti yuttuktan sonra par\u00e7alanmas\u0131na da yard\u0131mc\u0131 olur. T\u00fcm bu g\u00f6revleri ger\u00e7ekten \u00e7ok iyi yerine getirir.<\/p>

                  Ayr\u0131ca, PROSOLV\u00ae ad\u0131nda daha da etkili bir bile\u015fen serisi geli\u015ftirdiler. Bu seride, MCC\u2019yi \u00f6zel bir i\u015flemle ba\u015fka bir bile\u015fenle birle\u015ftiriyorlar. B\u00f6ylece, iki bile\u015fenin ayr\u0131 ayr\u0131 kullan\u0131ld\u0131\u011f\u0131ndan daha etkili olan tek bir \u201cs\u00fcper bile\u015fen\u201d ortaya \u00e7\u0131k\u0131yor. Bu sayede, y\u00fcksek kaliteli tabletlerin \u00fcretimi daha kolay ve daha ucuz hale geliyor.<\/p>

                  Bu geli\u015fmi\u015f bile\u015fenler, ila\u00e7 \u015firketlerinin i\u015flerini kolayla\u015ft\u0131rmaya yard\u0131mc\u0131 oluyor. B\u00f6ylece daha k\u0131sa s\u00fcrede daha kaliteli haplar \u00fcretebiliyorlar.<\/p>

                  Lubrizol<\/strong><\/h2>

                  Kurulu\u015f Y\u0131l\u0131: 1928<\/strong><\/p>

                  Ana \u00dcr\u00fcnler:<\/strong><\/h3>
                  • Topikal reoloji d\u00fczenleyiciler (Carbopol\u00ae polimerleri).<\/strong><\/li>
                  • Oral Kat\u0131 Form\u00fclasyonlar i\u00e7in Ba\u011flay\u0131c\u0131lar ve Matris Olu\u015fturucular (Carbopol\u00ae polimerleri).<\/strong><\/li>
                  • Kontroll\u00fc sal\u0131m i\u00e7in mukoadhezif polimerler (Noveon\u00ae polikarbofil).<\/strong><\/li>
                  • \u0130la\u00e7 salan cihazlar i\u00e7in termoplastik poli\u00fcretanlar (Pathway\u2122 TPU).<\/strong><\/li>
                  • Uzun Etkili Enjeksiyon Sistemleri i\u00e7in Polimerler.<\/strong><\/li><\/ul>

                    Lubrizol Corporation, Ohio eyaletinin Cleveland kentinde faaliyet g\u00f6steren bir \u00f6zel kimya \u015firketidir. \u015eirketin t\u0131p alan\u0131nda faaliyet g\u00f6steren birimi, Lubrizol Life Science Health olarak adland\u0131r\u0131lmaktad\u0131r.<\/p>

                    S\u0131radan, g\u00fcnl\u00fck kullan\u0131m ama\u00e7l\u0131 yard\u0131mc\u0131 bile\u015fenleri \u00fcretmiyorlar. Bunun yerine, \u00f6zel ve y\u00fcksek performansl\u0131 polimerler geli\u015ftirmeye odaklan\u0131yorlar. Bu polimerler, ila\u00e7lar\u0131n v\u00fccuda ula\u015fmas\u0131 s\u00fcrecindeki ger\u00e7ekten zorlu sorunlar\u0131 \u00e7\u00f6zmek i\u00e7in kullan\u0131l\u0131yor.<\/p>

                    En tan\u0131nm\u0131\u015f \u00fcr\u00fcnleri Carbopol\u00ae\u2019dur. Bu, \u00e7ok ilgin\u00e7 bir \u00f6zelli\u011fe sahip beyaz bir tozdur. Su ile \u00e7ok az bir miktar kar\u0131\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, su kal\u0131n ve berrak bir jele d\u00f6n\u00fc\u015f\u00fcr.<\/p>

                    Bu nedenle Carbopol\u00ae, say\u0131s\u0131z t\u0131bbi krem ve losyonun temel bile\u015fenidir. Bu madde, bu \u00fcr\u00fcnlere doku ve k\u0131vam kazand\u0131r\u0131r. \u00dcr\u00fcnlerin p\u00fcr\u00fczs\u00fcz ve ya\u011fl\u0131 olmayan bir his vermesini sa\u011flar.<\/p>

                    Ayr\u0131ca, di\u011fer ileri d\u00fczey uygulamalar i\u00e7in de polimerler \u00fcretiyorlar. \u00d6rne\u011fin, \u201cbiyo-yap\u0131\u015fkan\u201d polimerler \u00fcretiyorlar. Bu, v\u00fccudun nemli b\u00f6lgelerine yap\u0131\u015fabilmeleri anlam\u0131na geliyor. Bu \u00f6zellik, bir ilac\u0131 belirli bir b\u00f6lgeye uzun s\u00fcre boyunca ula\u015ft\u0131rmak i\u00e7in kullan\u0131labilir.<\/p>

                    Croda International<\/strong><\/h2>

                    Kurulu\u015f Y\u0131l\u0131: 1925<\/strong><\/p>

                    Ana \u00dcr\u00fcnler:<\/strong><\/h3>
                    • Biyolojik \u0130la\u00e7lar i\u00e7in Y\u00fcksek Safl\u0131kta \u201cSuper Refined\u2122\u201d Yard\u0131mc\u0131 Maddeler.<\/strong><\/li>
                    • LNP Form\u00fclasyonlar\u0131 i\u00e7in \u00d6zel Lipidler (Katyonik, Yard\u0131mc\u0131).<\/strong><\/li>
                    • A\u015f\u0131 Adjuvanlar\u0131 (Alhydrogel\u00ae, Adju-Phos\u00ae).<\/strong><\/li>
                    • Parenteral \u00c7\u00f6z\u00fcnd\u00fcr\u00fcc\u00fcler ve Em\u00fclgat\u00f6rler.<\/strong><\/li>
                    • Protein ve K\u00fc\u00e7\u00fck Molek\u00fcl Stabilizat\u00f6rleri.<\/strong><\/li>
                    • Topikal Yumu\u015fat\u0131c\u0131lar ve Penetrasyon Art\u0131r\u0131c\u0131lar.<\/strong><\/li>
                    • Y\u00fcksek Derecede Safla\u015ft\u0131r\u0131lm\u0131\u015f Oleokimyasallar.<\/strong><\/li><\/ul>

                      Croda International, \u0130ngiliz bir \u00f6zel kimya \u015firketidir. Merkezi Snaith adl\u0131 bir kasabada bulunmaktad\u0131r. \u0130la\u00e7 end\u00fcstrisi i\u00e7in son derece saf hammaddeler \u00fcretmesiyle tan\u0131nmaktad\u0131r.<\/p>

                      Bu saf bile\u015fenler, son derece hassas ve karma\u015f\u0131k ila\u00e7lar\u0131n \u00fcretiminde kullan\u0131l\u0131r. Biyolojik ila\u00e7lar ve a\u015f\u0131lar gibi \u00fcr\u00fcnleri d\u00fc\u015f\u00fcn\u00fcn.<\/p>

                      \u0130\u015flerinin en \u00f6nemli par\u00e7alar\u0131ndan biri, \u201cSuper Refined\u2122\u201d \u00fcr\u00fcn serisidir. S\u0131radan yard\u0131mc\u0131 bile\u015fenleri al\u0131p bunlar\u0131 ek bir temizleme i\u015fleminden ge\u00e7irirler. Bu \u00f6zel i\u015flem, b\u00fcy\u00fck sorunlara yol a\u00e7abilecek minik kirlilikleri ortadan kald\u0131r\u0131r.<\/p>

                      Bu neden bu kadar \u00f6nemli? Baz\u0131 yeni ila\u00e7lar, \u00f6zellikle biyolojik ila\u00e7lar, \u00e7ok hassast\u0131r. En ufak bir safs\u0131zl\u0131k bile bu ila\u00e7lara zarar verebilir ve onlar\u0131 kullan\u0131lamaz hale getirebilir. Bu son derece temiz bile\u015fenler ilac\u0131 korur ve \u00f6mr\u00fcn\u00fc uzat\u0131r.<\/p>

                      Son d\u00f6nemde Croda, en ileri d\u00fczey t\u0131bbi teknolojide \u00f6nemli bir akt\u00f6r haline gelmi\u015ftir. \u015eirket, mRNA a\u015f\u0131lar\u0131 i\u00e7in gerekli olan \u00f6zel lipitlerin, yani ya\u011flar\u0131n \u00f6nde gelen \u00fcreticilerinden biridir.<\/p>

                      Bu lipitler, mRNA molek\u00fcl\u00fcn\u00fcn etraf\u0131nda minik bir koruyucu kabarc\u0131k olu\u015fturur. Bu kabarc\u0131\u011fa lipit nanopartik\u00fcl veya LNP denir. LNP, mRNA\u2019n\u0131n v\u00fccudunuzda yapt\u0131\u011f\u0131 yolculuk boyunca g\u00fcvenli kalmas\u0131n\u0131 sa\u011flar. Ayr\u0131ca mRNA\u2019n\u0131n h\u00fccrelerinize girmesine de yard\u0131mc\u0131 olur.<\/p>

                      Ayr\u0131ca a\u015f\u0131 adjuvanlar\u0131 da tedarik ediyorlar. Adjuvan, a\u015f\u0131n\u0131n daha etkili olmas\u0131n\u0131 sa\u011flamak i\u00e7in a\u015f\u0131ya eklenen bir bile\u015fendir. Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminize a\u015f\u0131ya daha fazla dikkat etmesi gerekti\u011fini bildirir. Bu da daha g\u00fc\u00e7l\u00fc ve daha uzun s\u00fcreli bir ba\u011f\u0131\u015f\u0131kl\u0131k kazanman\u0131za yard\u0131mc\u0131 olur.<\/p>

                      \u00c7\u00f6z\u00fcm<\/strong><\/h2>

                      Hammadde \u00fcretimindeki en b\u00fcy\u00fck isimler, ila\u00e7lar\u0131n nas\u0131l \u00fcretildi\u011fini ve da\u011f\u0131t\u0131ld\u0131\u011f\u0131n\u0131 belirlemektedir. Bu \u015firketlerin sa\u011flad\u0131\u011f\u0131 bile\u015fenler, ila\u00e7lar\u0131n her yerdeki hastalar i\u00e7in tutarl\u0131, g\u00fcvenli ve etkili olmas\u0131n\u0131 sa\u011flamaktad\u0131r. Tedavi y\u00f6ntemleri giderek daha geli\u015fmi\u015f hale geldik\u00e7e, bu \u015firketlerin rol\u00fc de daha da \u00f6nemli hale gelecektir.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

                      Medicine depends on raw materials that make drugs safe and effective. A few companies stand out for supplying these essentials […]<\/p>\n","protected":false},"author":1,"featured_media":19355,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[65],"tags":[],"class_list":["post-19353","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-manufacturers"],"acf":[],"_links":{"self":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts\/19353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/comments?post=19353"}],"version-history":[{"count":1,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts\/19353\/revisions"}],"predecessor-version":[{"id":23001,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/posts\/19353\/revisions\/23001"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/media\/19355"}],"wp:attachment":[{"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/media?parent=19353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/categories?post=19353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmamachinecn.com\/tr\/wp-json\/wp\/v2\/tags?post=19353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}