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FTW Series Double Cone Mixer Pharmaceutical
The Cone Mixer consists of a frame, turnover hopper, lifting system, rotary system, and electrical control system. In a three-dimensional space in a closed hopper, powder materials are turned forcefully and diffused in a contraction effect to mix them. The mixing uniformity rate reaches 99% or more, with a residual amount of less than 0.1%, in full compliance with GMP standards. The Cone Mixer can be used to production of tablets, capsules, powders, and nutritional supplements.
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Key Features
Technical Data
Machine Details
FAQ
Application Powder Types
1. The machine has fixed double columns, an automatic feeding system, and a mechatronic mixing system. It is easy to operate and set running program.
2. This mixer improved efficiency and avoids cross-contamination.
3. The entire mixing process is completed in a closed barrel, with a mixing uniformity rate over 99%, a volume loading system reaches 80%, and a 316L inner wall, 304 body.
4. The Cone Mixer is compatible with volume ranging from 5L to 2,000L and is especially designed for mixing materials of poor fluidity.
5. High mixing efficiency, low energy consumption, easy operation, cleaning, and maintenance.
6. PLC human-machine interface automatic control system with hierarchical management authority, which meets the tracking and traceability requirements of certification processes such as FDA/GMP.
7. Application: Active Pharmaceutical Ingredients (APIs), Combining spices and seasonings, Blending detergent powders and cleaning compounds, Powdered Water Soluble Fertilizer.
| Model | FTW-50 | FTW-100 | FTW-150 | FTW-200 | FTW-300 | FTW-500 | FTW-1000 |
| Total Volume (L) | 50 | 100 | 150 | 200 | 300 | 500 | 1000 |
| Maximum Loading Capacity (L) | 25 | 50 | 75 | 100 | 150 | 350 | 700 |
| Maximum Loading Weight (kg) | 25 | 50 | 75 | 100 | 150 | 210 | 420 |
| Motor Power (kW) | 0.75 | 0.75 | 1.1 | 1.1 | 1.5 | 2.2 | 4 |
A Double Cone Mixer is a gentle, tumble-type blender used for dry powder and granule mixing. It consists of two conical sections welded to a central cylindrical shaft. The entire vessel rotates on its horizontal axis, causing the material to be lifted and then tumbled back on itself in a continuous, cascading motion. This low-shear, diffusive mixing action ensures a uniform blend without damaging particle structures.
It is ideal for pharmaceuticals due to its:
Gentle Blending: Prevents attrition or heat generation of sensitive Active Pharmaceutical Ingredients (APIs) and granules.
Uniform Homogeneity: Achieves excellent blend uniformity for consistent dosage.
Minimal Segregation: The gentle tumbling action minimizes the separation (demixing) of different particle sizes or densities.
cGMP Compliance: Designed with polished stainless steel (304 or 316L), no dead zones, and features for easy cleaning and validation.
Versatility: Suitable for blending APIs, excipients, dry powders, and granules.
Sanitary Construction: Mirror-finished internal surfaces (Ra ≤ 0.4 µm).
Sealed System: Glandless seals or advanced mechanical seals to prevent lubrication contamination and product leakage.
Easy Cleaning: Options for Clean-In-Place (CIP) systems, rapid discharge valves, and easy disassembly.
Smooth Surfaces: Internally welded joints, polished to prevent material adherence and microbial growth.
Documentation: Support for DQ, IQ, OQ, PQ protocols and 3.1 material certificates.
Uniformity is validated through a Performance Qualification (PQ) protocol using tracer studies (e.g., a colored or soluble tracer like Riboflavin). Samples are taken from multiple predetermined locations after a set number of rotations. The content uniformity is analyzed via HPLC or UV spectroscopy to prove the mixer achieves a homogenous blend (typically with an RSD of ≤ 5%).
The optimal working volume is typically 50-60% of the total gross volume. Under-filling (below 30%) reduces mixing efficiency, while over-filling (above 70%) impedes the cascading tumbling action, leading to poor blending.
The optimal working volume is typically 50-60% of the total gross volume. Under-filling (below 30%) reduces mixing efficiency, while over-filling (above 70%) impedes the cascading tumbling action, leading to poor blending.
Yes. Modified designs include:
Containment Systems: Split butterfly valves, sealed loading/unloading ports.
Potent Compound Handling: Integrated glove boxes, wash-in-place (WIP) systems, and negative pressure operation to protect operators and the environment (OEB levels 4-5).
Not for Wet Mixing: Designed for dry solids only.
Not for Cohesive Powders: Extremely sticky or cohesive materials may not blend effectively without additional agitators.
Density/Size Differences: Large differences in particle size or density can still lead to segregation; formulation science is key.
Regular inspection of seals and bearings.
Verification of drive belt tension and motor alignment.
Periodic re-calibration of speed sensors.
Post-campaign cleaning and visual inspection per SOPs.
1. Pharmaceutical & Healthcare
Medicine manufacturing: Mixing active drugs with fillers, binders, and lubricants for tablets/capsules
Nutritional supplements: Protein powders, vitamin blends, meal replacements
Medical products: Antibiotic powders, contrast agents, surgical powders
Dental products: Tooth powder formulations
2. Food & Beverage
Instant products: Soup mixes, drink powders (coffee, tea, chocolate), dessert mixes
Spices & seasonings: Blended spices, gravy powders, seasoning packets
Bakery mixes: Cake mixes, bread premixes, icing sugar blends
Nutritional products: Infant formula, sports nutrition, fortified foods
3. Chemicals & Industrial
Detergents & cleaners: Laundry powder, dishwasher detergent, industrial cleaners
Construction materials: Dry mortar, tile adhesives, cement additives
Plastics & polymers: Color masterbatches, filler compounds, polymer blends
Explosives & pyrotechnics: Firework compositions (safely engineered)
Agriculture: Fertilizer blends, pesticide powders, seed coatings
4. Cosmetics & Personal Care
Makeup: Foundation powders, eyeshadows, blush
Skincare: Talcum powder, medicated body powders
Cosmetic additives: Pigment blends, glitter mixtures
5. Advanced Materials
Metal powders: Alloy preparations for 3D printing (additive manufacturing)
Ceramics: Technical ceramic formulations
Batteries: Electrode material blends for lithium-ion batteries
Electronics: Conductive paste powders, solder blends
