High-Speed Rapid Mixer Granulator

An RMG is a single-pot, multi-functional machine used primarily in solid dosage (tablet/capsule) manufacturing. It performs three key operations in one vessel: dry mixing of powders, wet granulation by adding a binder liquid, and wet massing to form agglomerates.

To convert fine, poor-flowing, non-compressible powder blends into free-flowing, compressible granules suitable for tablet compression or capsule filling. This improves content uniformity, flow, and density.

• Single-Pot Processing: Mixing, granulation, and wet massing in one place reduces material handling, time, and contamination risk.

• Better Control: Precise control over impeller/chopper speed and liquid addition rate leads to consistent granule quality.

• Efficiency: Faster processing and reduced solvent/binder usage.

• Reproducibility: Critical for regulatory compliance (GMP).

Yes, an RMG is essentially a high-shear granulator. The high-speed impeller and chopper impart significant shear force, producing dense, spherical granules.

• Impeller Speed: Affects mixing efficiency and granule density.

• Chopper Speed: Controls lump breaking and granule size distribution.

• Binder Addition Rate & Method: Spray rate and nozzle position affect uniformity.

• Mixing & Massing Time: Under- or over-massing can lead to poor granules.

• Product Temperature: Can rise due to shear; needs monitoring.

The point where optimal granule characteristics are achieved. It’s determined by empirical observation (e.g., consistency) or, more scientifically, by monitoring power consumption/amperage of the impeller motor or torque. A sharp rise indicates the desired endpoint.

Yes. Excessive mixing time (over-massing) after liquid addition can lead to too hard or too dense granules, which may cause capping, lamination, or poor disintegration in the final tablet.

• Top-Driven: The motor is above the bowl. Easier maintenance, no risk of lubrication leakage into the product, but can have larger footprints.

• Bottom-Driven: The motor is below the bowl. More stable drive, easier bowl handling/tipping, but requires superior seals to prevent product contamination from the gearbox.

Stainless Steel 316L is standard for pharmaceutical use. Contact surfaces are polished to a pharmaceutical finish (e.g., Ra < 0.4 µm) for easy cleaning and preventing material adhesion.

 User Requirements Specification (URS), Design Qualification (DQ), Installation Qualification (IQ), Operational Qualification (OQ), Performance Qualification (PQ), Standard Operating Procedures (SOPs), maintenance logs, and cleaning records.